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COVID vacccines are you ready for another go?

As you are aware the UK was the first place to approve COVID-19-related vaccinations in late 2020. Vaccines were made so fast because the virus was identified and the sequence was given to the World. This is known to some a Wuhan strain or the A strain or the Index Virus. The first major variant to surface in the UK was called the UK/Kent strain but was given an offical number B.1.1.7. It was...

Is Ocrelizumab getting rid of EBV

You have had NDGs take on this paper earlier and as I had done a post befiore I realised she had done the same thing, you may as well have it as an alternative view Zivadinov R, Jakimovski D, Ramanathan M, Benedict RH, Bergsland N, Dwyer MG, Weinstock-Guttman B.Effect of ocrelizumab on leptomeningeal inflammation and humoral response to Epstein-Barr virus in multiple sclerosis. A pilot study ...

Spot the mistake? A self-fulfilling hypothesis

En face this research seems straightforward, but upon reading the methodology of the manuscript my first thought was ‘huh’? Why the ‘huh’? Well, if you’re going to study on humoral immunity (i.e. antibody formation), the drug not to use is Ocrelizumab or any other anti-CD20 for that matter. The MOA (mode of action) of anti-CD20s is to target B-cell function and...

Loss of Antibody with anti-CD20 associated with poor COVID response

Bellinvia A, Aprea MG, Portaccio E, Pastò L, Razzolini L, Fonderico M, Addazio I, Betti M, Amato MP Hypogammaglobulinemia is associated with reduced antibody response after anti-SARS-CoV-2 vaccination in MS patients treated with antiCD20 therapies. .Neurol Sci. 2022:1-12. doi: 10.1007/s10072-022-06287-2. Online ahead of print Background: COVID-19 vaccination is highly recommended to multiple...

What does an MS lesion look like to the naked eye?

You asked what does an MS lesion look like not by MRI or undr a micoscope to paraphrase “I have ….10mm lesions” Sorry I don’t want to put you off your lunch but this is a picture of human brain with MS. The whitety pink bit on the inside is the white matter consisting of nerves and on the outside of the brain is the grey matter. There is a ruler and I think you can see...

Protecting oligodendrocytes

Many years ago we were interested in cannabis as a nerve protector and one way we thought that it worked was to control nerve excitability. Nerve excitation is associated with electrically charged calcium and sodium entry into the cell making the inside cell more positive and if you get too much excitation it triggers cells to die by cell suicide. As a result of cannabinoid receptor stimulation...

Predicting natalizumab response

The story starts with the observation that certain types of antibody are found in MS and their presence is associated with evidence of antibody activation that causes damage. This antibody type is called IgM which is often the first type of antibody produced. They found that many people with MS showed antibody responses to phosphotidylcholine (PC) . They suggest that serum IgM-PC is a candidate...

Protecting yourself from the influence of DMF….Time for another pie:-)

Yes this is a not so serious post, on a serious matter. Dimethyl fumarate can cause white blood cells to drop and this is a risk factor. This study is a data mining study and reports on factors that promote disappearence of white blood cells…..one is being old and the other is being too thin. They also looked at sex and white blood cell levels. In most cases these are not things you can do...

ProfG’s real MS

People work on what interests them and what they can get funding to do. But we have been challenged to switch focus to work on the “Real MS”…but what is it.? Would it be sensible to all work on the same thing, because what if the idea is wrong? You can read this review to get ProfGs idea. (He wrote the original version and the rest conceptulaized and edited). However the...

Recruitment we need more than a Trial Linked-In.

I was recently chastised for not working on the “real MS” what ever that is. But if I do come up with something for the “real MS” then it will need a trial, otherwise people are unlikely to accept the evidence. However, as I have said before “trials kill MS treatments” because sometime the people entering a trial is not optimised…So studies fail because...

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