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Guest post: Losing and resetting my identity

Rachel Horne wrote a guest post on 15 July called Identity. I think just about everyone who has had MS will have gone through at least one personal crisis and hopefully come out the other end. This is my personal crisis story or losing and regaining my identity and written with the benefit of hindsight. Diagnosis I was diagnosed in 1995 with RRMS. In those days the mobile phone was similar to a...

Guest post: Oceans of Hope is coming to Edinburgh

Visit us in Leith Harbour Oceans of Hope is still sailing – back in 2014 to 2015 we sailed around the world in our 67 feet steel sailing boat crewed by PwMS. This summer we are going to Scotland. On August 19 we are visiting Edinburgh and hosting an event in Leith Harbour together with MS Brain Health, Anne Rowling Clinic, EMSP and the MS Society Scotland. From MS Brain Health and Barts we are...

Animal Studies need to pull their socks up and be more transparent!

If people are working with animals, especially those of a severe nature, then is it time to change! In this report we suggest that what people are calling progressive EAE is nothing more that relapsing-remitting EAE that is ascychronous with increasing poor recovery. This is important because we know that relapsing EAE responds to T cell therapy but we want alternative treatements for progressive...

Memory B cells during Symptoms.

This study looks in the blood when someone gets a hearing problem..They find mature naive B cells. Are these the problem. Where are the memory B cells they aren’t there..Maybe they have moved out of the blood to cause the problem. Lymphocytes B population profile in a case of multiple sclerosis presenting with sudden sensorineural hearing loss caused by a demyelinating pontine...

Aaron Boster is Ace

I’m part of the Aaron Boster fanclub. He is an American neurologist who inhabits the social media space. In this video he asks questions of the old school (dinosaur) and new school neurologist……. Love it and he has three shirts… although two sound like the same one:-) Sadly there are plenty of the “old school” neurologists about. They should carry a health...

Thyroid disease with Alemtuzumab – risk mitigation

There is a popular old saying in English – “forewarned is forearmed”. Prior knowledge that something is going to happen offers tactical advantage, whether you’re at war or simply everyday life. The difficulty, however, is that more often than not we are transfixed by the detail of the matter, resulting in numerous avenues of investigation in the process, some of which are...

Converting to SPMS, worse thing is uncontrolloed worsening

Risk of secondary progressive multiple sclerosis: A longitudinal study.Fambiatos A et al. Mult Scler. 2019 Aug 9:1352458519868990 BACKGROUND:The risk factors for conversion from relapsing-remitting to secondary progressive multiple sclerosis remain highly contested. OBJECTIVE: The aim of this study was to determine the demographic, clinical and paraclinical features that influence the risk of...

Education Doube negative memory

In humans B cells can be recognised by the expression of CD19 (a molecule involved in B cell antigen receptor signalling and B cell diferentiation into different B cell sub-types). Memory B cells are recognised by the presence of a marker called CD27 (as survival factor receptor and activation marker also found on activated T cells) and Immunoglobulin (antibody) arrangements. Antibodies serve are...

Looking in the blood or brain for inflammatory markers

NDG may have something to say about this one. In this study they looked for inflammatory markers in the blood and spinal fluid in people with MS. I have removed the bits about predictors as those familiar with the blog, know that these are generally never good enough to say anythng about the individuals. The point I want to make is this, that you may been to be prepared to have a lumbar puncture...

Mortui vivos docent

We haven’t done this in a while but the post from the Cleveland Clinic, reminds me to remind you to consider donation of your tissues You can watch a video here To Registered please visit here MS Society Tissue Bank If you live in the States read this Comprehensive Autopsy Program for Individuals with Multiple Sclerosis.Dutta R, Mahajan KR, Nakamura K, Ontaneda D, Chen J, Volsko C...

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