Ask a question this is the place for you. You want art and as this is the last few days of the LeedsBear Hunt 2023
The Auction of your favourite for Good causes is happening soon
Ask a question this is the place for you. You want art and as this is the last few days of the LeedsBear Hunt 2023
The Auction of your favourite for Good causes is happening soon
We often discuss MS in isolation to other autoimmune disorders, but how does it stack up against them? Given the choice if you were a woman of childbearing age and knowing the relative risks of childbirth which is the ‘safest’ autoimmune disorder to have? In the Table below (Table 1) you can see the figures from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD)...
You know that I’m not that bothered with these “this is my new clinial trial” papers but it let’s you know what is happenening and it may help the trials to recruit people. This is a remyelination study so I thought that you may be interested as its not all about relapses. However, unfortunately you will have to wait for the results Re-WRAP (Remyelination for women at risk...
There have been a number of requests to make a comment on a recent post about “reverse vaccines” that programme the treatment to go to the liver to turn off the immune response. I could put a link but all that happens is the authors follow the altmetric and come to the blog and if I don’t gush about it they get abit miffed. So best not bother but simply to say if you made the...
Yesterday we had the pleasure of meeting Amy and the Team for the Launch of a New Charity called MS-together. (www.mstogether.org) This centres on Young People with MS…including “Queenagers”
We wish them every success in their new adventure
Some familiar Faces…..Some Not…….Some Couldn’t make it….Some Gone….Someone’s First Day..
A clue…………………………………Welcome Ester
It is not often we get together to see what changes we can make and whats round the corner.
Yep the title has nothing really to do with the paper today, but it asks a question about escalation and high efficacy agents. I think FFS, how long is it going to take before this sinks in. That Pharma are doing trials against the Lower Efficacy Therapeutic agents knowing that their new drugs will succeed…..asks “Why are we still using this escalation approach knowing that there is a...
N-Acetylglucosamine (GlcNAc) is an amide derivative of glucose it is part of chitin which forms the skeletions of insects and the cell wals of bacteria from fungi. O-GlcNAcylation is the process of adding a single N-acetylglucosamine sugar to amino acids in proteins and is a means of activating or deactivating enzymes or transcription factors. But I am sure it is the...
Natalizumab has come out of patent and gneric natalizumab is arriving, so what do you you do? Yep you reformulate for subcutaneous (injected under the skin) delivery. The manufacturers of ocrelizumab have also looked at the different routes. Ofatumumab is an antibody delivered once a month under the skin at home. Is this the plan for natalizumab? Well no at present you have to go into hospital...
Teriflunomide is what I call a dark horse in the DMT family, doesn’t get much air time but every clinical trial of a new agent trumpets its success without meaning to. For example, it’s brain atrophy data makes the anti-CD20s look inadequate, it’s safety profile (despite the overzealous monitoring required by the regulatory authorities) is good, plus you can get rid of the...
OK I made the title up, but pick your drug, pick your sexuall transmitted disease (STD) and ask yourself if you locked yourself away for two years and didn’t see anybody and didn’t have sex. What are the chances are you would catch an STD? Higher or lower? Now I’m no rocket scientist but I bet it would be lower. Now we have todays post. Dwyer C, Sharmin S, Kalincik T. Rates of...