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Q&A June and Thanks from ProfAngry

Just a thank you to anybody who contributed to ProfA’s sponsored Ride about London and Essex. He reached his target thanks to your help The ride was 100 miles plus the ride from home to central London to the start and back He went into the country Never looked lost….Afterall its Chingford Lane close to the Leyton triangle Then back to the ‘Smoke’ (an old name for London)...

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CD20-depleters and infection risks

So first things first, i have to say that rituximab is not approved for use in MS. However what does this say? If you contiuously and substantially deplete B cells you get a reduced capacity to make antibody responses. We know this because of COVID-related vaccines. Ths can be seen by a drop in circulating IgM (5 armed antibodies) then with time a drop in IgG(one armed antibody) and IgA (two...

Q&A June and Thanks from ProfAngry

Just a thank you to anybody who contributed to ProfA’s sponsored Ride about London and Essex. He reached his target thanks to your help The ride was 100 miles plus the ride from home to central London to the start and back He went into the country Never looked lost….Afterall its Chingford Lane close to the Leyton triangle Then back to the ‘Smoke’ (an old name for London)...

What could you do if you are in AttackMS or on natalizumab. What will you switch too

AttackMS aims to treat people with first presentation of MS with natalizumab. This aims to give the team breathing space to confirm diagnosis and help stop the second attack occuring whilst this process is ongoing. It hopes to allow repair to occur. However, what happens next is up to the individiuals who can chose to stay on natalizumab or switch to ther preferred option therefore what happens...

CMSC 2023 – Epstein Barr Virus controversy

This year I was at the CMSC to speak about serum neurofilament proteins in Aurora, Colorado. Needless to say this one is ready for prime time and the audience was in agreement for once. Whilst I was there I also took the opportunity to see some other sessions that interested me. One that had me thinking was the debate session on ‘Tackling MS controversies: hot topics in multiple...

2023 EAE Cure of the Week…Game changing..Again

Rhodes KR, Tzeng SY, Iglesias M, Lee D, Storm K, Neshat SY, VanDyke D, Lowmaster SM, Spangler JB, Raimondi G, Green JJ. Bioengineered particles expand myelin-specific regulatory T cells and reverse autoreactivity in a mouse model of multiple sclerosis. Sci Adv. 2023;9(22):eadd8693. Multiple sclerosis (MS) is an autoimmune disease characterized by autoreactive immune cells damaging myelinated...

How do CD8 T cells get in the brain.

This paper concerns itself with CD8 T cells. These are reported to be the major T cell population entering the CNS in MS.. Here, they sart by suggesting that endothelial cells present antigen to CD8 T cells and that promotes entry into CNS. They suggest that the CD8 T cells trigger death of the blood vessel cells and cells then enter the CNS….but is it in vitro (in cell culture) in smeetro...

Ofatumumab and COVID-19 vaccination

The SH1 stuck to rituximab and ocrelizumab for inducing a poor response to COVID-19-related vaccines…because they were being used alot during the pandemic. Ofatumumab avoided the bad news as it want’t used as much but as it could be given at home and thus avoided a trip into hosptial for treatment. The Dresden group has been at the forfront of looking at the influence of DMT on SARS...

Normal white matter…not so normal

Normal appearing white matter is not so normal in MS so this study speaks to the real MSers and inflammation is just an after thought and our neuros have been barking up the wrong tree. However, not too quick in this study they find abnormalities in the myelin and nerves requiring more energy…but they find some evidence of inflammation and the correlation is r=0.7-0.9, which is real...

CD40 Ligand blockade. How does it work?..Blocking T cells….inhibiting B cells? or Influencing EBV?

Banging on the B..eat SH1 I have been banging on about B cells for what seems like the last decade, but when ever I suggest that MS drugs may be working by targeting B cells, the reviewers say “What about T cells? Because the drugs all work through T cells! and I am scared of reading your thoughts, if you don’t mention T cells, T cells, T cells”. It is not surprising as the...

COVID making impact

Silly season is looming and the research assessment coming up in a few years time and we will be throwing thousands at the metrics to get impact so should we make some claims. Years ago we said that ocrelizumab was being dosed too frequently and that we could dose less frequently and maintain effidacy. Covid came along and proved that view over and over again….is that Impact? Guerrieri S...

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