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What the eye doesn’t see?

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I saw someone with possible MS earlier this week and he had been told that he couldn’t have MS because he only had one detectable lesion on his MRI. Is this correct? The problem: ‘MS has become an MRIscopic disease’. The diagnosis of MS remains clinical and is underpinned by the need to show (1) dissemination in time (typically new activity 4 weeks apart or the presence of...

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Self-neglect: the hidden burden of having MS

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You may recall my post on using the foot examination to look at the state of my patients’ toenails as an indicator of neglect. Another window is the mouth and the state of a person’s teeth and gums. Self-neglect is a problem in MS. But how big is the problem? The study below using an online survey shows that pwMS have a greater oral health burden than the general population; i.e. they...

What the eye doesn’t see?

W

I saw someone with possible MS earlier this week and he had been told that he couldn’t have MS because he only had one detectable lesion on his MRI. Is this correct? The problem: ‘MS has become an MRIscopic disease’. The diagnosis of MS remains clinical and is underpinned by the need to show (1) dissemination in time (typically new activity 4 weeks apart or the presence of...

EAE Cure of the Week…Plasma cells protect MS

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As profG and NDG gear up to do a study to try and get rid of antibodies from the brain, I read with horror the latest effort of microbiome in animal models in a world premier journal.  It says plasma cells make MS better! So should we abandon the trial? I was worried so I thought I best have a look at the data. As you know I don’t think that studies of B cells in mice tells us much and...

Targeting B cells Slows Progressive MS…..Wakey, Wakey People monotherapy is so last century.

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In the News today CD20-Depletion appears to have benefit is SPMS… But what does it say to me? Time to start learning and acting on the knowledge! Naegelin Y, Naegelin P, von Felten S, Lorscheider J, Sonder J, Uitdehaag BMJ, Scotti B, Zecca C, Gobbi C, Kappos L, Derfuss T. Association of Rituximab Treatment With Disability Progression Among Patients With Secondary Progressive Multiple...

Loneliness in 2019

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Rehabil Nurs. 2019 Jan/Feb;44(1):52-59. doi: 10.1097/rnj.0000000000000128. Loneliness in Multiple Sclerosis: Possible Antecedents and Correlates. Balto JM, Pilutti LA, Motl RW. Abstract PURPOSE: The prevalence and possible antecedents and correlates of loneliness in multiple sclerosis (MS) was examined. DESIGN: Cross-sectional, comparative study of MS (n = 63) and healthy adults (n = 21)...

MMR to test or not to test?

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Can I assume you know about Andrew Wakefield and the fake link between the MMR vaccine and autism? Despite Wakefield being discredited and struck off the medical register in the UK he, and the ‘Anti-Vax’ brigade, is still having a profound impact on society, which is gradually beginning to filter down to how we manage MS. Why? The number of children receiving the MMR vaccine in...

Barts-MS Hangouts 2019

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Reconnecting in 2019! As we will not be hosting a large MS Research Day in 2019 (it is not our turn) we propose taking up the challenge, as suggested by one of our blog commentators, and doing regular online hangouts. Hangouts are an easier and cheaper version of a physical meeting. We need your thoughts on whether or not this is needed and the format of the hangouts. Thanks. ...

January Q& A 2019

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The New Year has arrived and Now has the Q&A post use it to ask those questions that are unrleated to the posts.

I have not put snowy picture because in my Garden the buds are popping and the new leaves are arriving, I fear to be eaten by the next “Beast from the East” ,so for the insomniacs or early risers we have a lunar eclipse.

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