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Headaches

Mavridis T, Papagiannakis N, Breza M, Vavougios GD, Patas K, Daponte A, Laskaratos A, Archontakis-Barakakis P, Pantazopoulos I, Mitsikostas DDB-Cell Targeted Therapies in Patients with Multiple Sclerosis and Incidence of Headache: A Systematic Review and Meta-Analysis. .J Pers Med. 2022 Sep 8;12(9):1474. doi: 10.3390/jpm12091474. Background: Multiple Sclerosis treatment with B...

Continuous CD20-depletion or Not

Should anti-CD20 be used as an immune reconstitution therapy? The debate Rolfes L, Meuth SG. Stable multiple sclerosis patients on anti-CD20 therapy should go on extended interval dosing-“YES”. Mult Scler. 2022; 28:691-693 Anti-CD20 antibodies such as rituximab proved powerful yet remained as an off-label treatment in multiple sclerosis (MS) until the approval of ocrelizumab in 2018...

Ofatumumab and COVID

Faissner S, Heitmann N, Plaza-Sirvent C, Trendelenburg P, Ceylan U, Motte J, Bessen C, Urlaub D, Watzl C, Overheu O, Reinacher-Schick A, Hellwig K, Pfaender S, Schmitz I, Gold R. Immune response in ofatumumab treated multiple sclerosis patients after SARS-CoV-2 vaccination. Front Immunol. 2022 Aug 31;13:980526.  Objective: The pandemic induced by SARS-CoV-2 has huge implications for...

Human Zebras and Mice

Zebra fish have stripes and is a model species used to understand biology Zebrafish are a model animal species and are used as they are transparent in early life and there genes can be manipulated to express colours associated with expression of proteins such as the green and red above. You can also make fish that express fluorescent myelin In this study, they remove a fish gene (GPR17) and...

Inauguration Day

No, not THAT type of inauguration on the US Capitol facing the National Mall, but rather facing an audience in the Blizard Institute’s Perrin Lecture Theatre, colour scheme of which is modelled on a Poppy field, as ‘In Flanders Fields‘, with mostly green and a few dotted red seats. ProfAngray and myself gave our inaugural lectures there last night, in my case this was three...

Can anti-viral agents show us the viral cause

Sedaghat N, Etemadifar M. Revisiting the antiviral theory to explain interferon-beta’s effectiveness for relapsing multiple sclerosis. Mult Scler Relat Disord. 2022;67:104155. doi: 10.1016/j.msard.2022.104155 Treatments with interferon-beta (IFNβ) – a cytokine with established antiviral effects – were initially considered for multiple sclerosis (MS), as epidemiological data...

“Success” Remyelination

Here are additional results from a study with Bexarotene, which suggest some success. However, the trial is viewed as a failure. This is because the intended outcome aim wasn’t seen. You have to define this before the trialfinshes to stop you picking and choosing the positive outcome. However, it bodes better for the next study. However, Bexarotene is unlikely to be developed because it...

Ponesimod in RRMS – long-term clinical trials

Ponesimod, like fingolimod and siponimod preceding it block the ability of lymphocytes to leave the lymph nodes, thereby lowering circulating lymphocytes. As such the clinical effect is similar in the broad sense to that of it’s parent compounds – this includes efficacy and side effects. Unlike fingolimod (2nd line for active RRMS in the UK) and siponimod (reserved for active SPMS in...

A Day to remember

Today is a sad day as Her Majesty the Queen Elizabeth II is buried. We send our condolences However, today there is no sitting in front of the tele as we have the first physical science meeting attended this year and the first for many since lock down. The “At the Limits 2022 MS meeting” is surprisingly going ahead at the Royal College of Physicians for monday and tuesday. Programme...

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