Ocrelizumab (anti-CD20) that targets B-cells was given as two treatment cycles, 6 months apart, in a phase 2 study in relapsing-remitting MS. It reduced MRI activity by ~90% (median T1 Gd-lesions at wk 24: placebo 1.6, 600mg 0.0, 2000mg 0.0, Avonex 1.0; p
Improvement in MS disability after Alemtuzumab
Treatment of early RRMS with Alemtuzumab reduces relapses and the accumulation of disability compared to interferon β. Remarkably PwMS treated with alemtuzumab experienced an improvement in disability at 6 months that was sustained for at least 3 years in comparison to those treated with interferon β. Critics have poopooed this observation as the study was single-blinded and liable to unblinding;...