Racke et al. Neuroprotective Potential of Fumaric Acid Esters in a Model of Multiple Sclerosis. P05.032.
BG12 = Fumaric Acid Esters or dimethyl fumarate (DMF)
Pretreatment of mice with DMF reduced inflammatory lesion size by 30% and behavioral performance or recovery by 50%.
“In view of the positive phase 3 results and the mode of action of BG12 these results are very exciting. I still believe that BG12 will be an ideal add-on drug to existing anti-inflammatory DMDs.”
COI: I sit on the steering committee for the BG12 phase 3 programme and receive consultancy fees for this role.