ArchiveAugust 2011

Research: my lesion load has just gone up

Epub ahead of print: de Graaf et al. Lesion detection at seven Tesla in multiple sclerosis using magnetisation prepared 3D-FLAIR and 3D-DIR. Eur Radiol. 2011 Aug 27.  MRI scanners can be classified on the strength of their magnets. A typical diagnostic scanner is 1.5 Tesla with newer models being 3 Tesla. This study examined the feasibility and value of a 7 Tesla scanner...

Comment re laquinimod

Mr Giovannoni, I don´t think it serious to refer to an analyst/equity researcher at an investment bank regarding laquinimods be or not to be. No offence, but should know that. Also, I think you are dismissing or press down the prospects of laquinimod wrongly. NOT A PRETTY MS MARKET – DOG EAT DOG BEHAVIOUR Those investment bankers/analyst have loyalty to different MS-company´s (read:...

Research: clinical scales in progressive MS

Epub ahead of print: Bosma et al. Clinical scales in progressive MS: predicting long-term disability. Mult Scler. 2011 Aug 25. Background: The aim of this study was to determine which short-term changes on clinical scales including the Expanded Disability Status Scale (EDSS), Timed 25-Foot Walk (T25FW), 9-Hole Peg test (9HPT) and Guy’s Neurological Disability Scale (GNDS) are...

Research: antibody production and cortical lesions

Epub ahead of print: Calabrese et al. The association of intrathecal immunoglobulin synthesis and cortical lesions predicts disease activity in clinically isolated syndrome and early relapsing-remitting multiple sclerosis. Mult Scler. 2011 Aug 25. Background: The production of immunoglobulin by B cells and plasma cells within the brain and spical cord is a major biological feature...

Digesting Science

There seems to be some misunderstandings in relation to the “Digesting Science” series of post. I would strongly recommend that you look at Alison Thomson’s site, which explains her work and the motivation behind it. Her work was not done for the blog. From our perspective it has been great collaborating with her; not only is it interesting and engaging, but a fresh look at...

Reporting about the blog

Hello Prof G, I follow your blog, the articles about CCSVI treatment seem to appear ever so often. I think enough has been said this form of treatment for the time being. The publication of the NICE document seems to be a good opportunuty to put the whole issue to bed for a while. Another thing, I think it would be interesting to see a name against a reply that is made to an entry or piece of...

Disease course of PPMS

In response to the previous comment from the MS’ers with PPMS, who needed a walking aid within 4years of disease onset and malignant MS.  The following is the survival curve in relation to PPMS. As you can see only ~8% of MS’ers with PPMS need a walking stick within 4 years (red); this is twice the progression rate of the average, i.e. 50% require a walking aid within 8 years...

CCSVI – NICE Consultation Document

Provisional recommendations 1.1 Current evidence on the efficacy and safety of percutaneous venoplasty for chronic cerebrospinal venous insufficiency (CCSVI) in multiple sclerosis (MS) is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of research. 1.2 NICE encourages further research on venoplasty for CCSVI in MS. Clinical trials should be...

Espresso clinical tutorial (1): Fulminant MS or Marburg’s variant

In response to a comment yesterday: Marburg’s variant of MS, which is also known as fulminant MS, is quite rare. It was initially described by the Austrian neurologist Otto Marburg.  The term fulminant is a carry-over from the pre disease-modifying therapy era. Most cases presenting with Marburg’s variant of MS who treated promptly with appropriate therapies...

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