ArchiveAugust 2011

Drug The Game Part II

As you have seen the pecha kuca from Prof G I present mine in a much more low tech way. Drug-Game Part 1 Why Does it take So Long to Develop a Drug For MSersFind Out! Play…….Drug You now have your Piece to Start……..DrugBasic RulesFile Patent to Start (Throw a six pay £100,000). The patent gives you legal protection to develop your drug for a number of years before...

Schtop or Not. Pregnacy and MS

A New Study from the Netherlands has been looking at the effect of Pregnancy on MSers. As is well known the relapse rate decreases during pregnancy, but as is known to occur there was a surge in relapses within 3 months after the birth. However when doctors looked at 9 months after birth compared to before birth, there was no worsening n indicators of MS. Therefore no adverse effects of pregnancy...

MouseDoctor Bio

You Said “May I ask people to sign their post, and maybe add their bio’s next to G’s ?” “Who’s the MouseDoctor?”Simples…the MouseDoctor (Matter) is the alter ego of….Prof. Brain Cox (Anti-Matter) ” I (Matter) Nearly touched him (Anti-Matter) at Cheltenham Science Festival a few weeks ago…We could have both gone up in a puff of...

UK Stem Cell Trial is Full

Given the Media Coverage of Stem Cells Last WeekThe Trial for Bone Marrow Transplantation by Dr Muraro is Recruited.They Do Not Need Any More Volunteers, So Please Do Not Contact themIt is wasting Both Your and Their Time “Not sure If they are actually using mesenchymal stem cells, I now think it could be just a bone marrow transplant. This is away of reprogramaming the Immune System and in...

Drug-The Game-Part I

As you have seen the pecha kuca from Prof G I present mine in a much more low-tech way. Each day we hear about drug-treatment this and drug-treatment that,but why aren’t you doing something and giving me a drug that will work for MS? The MS community is trying!. Drugs are appearing with increasing frequency, but progress is painfully slow!. Why is this the case? The answer is in Drug...

Using Animals to Probe Inflammation in MS

If you Look Down A Microscope at a bit of Brain Tissue From Someone with MS, which was stained with a dye that picks up the nuclei of cells. You sometimes see accumulation of cells around blood vessels (veins) “What are they?, How Does they Occur? Can we Stop them occurring?”.What are they?You can stain the brain tissue from MS and see that they are white blood cells using markers on...

Don’t Shoot the Messenger!

Another failure in MS and the EAE-bashers are out Following the sad news that a new trial laquinimod had just failed to show a significant effect in MS. The first post is: ” Anonymous said… Another EAE failure:” “Here is a wonderfully optimistic paper on how laquinimod healed mice: Insight into the mechanism of laquinimod action. Brück W, Wegner C”. First remember...

Gingseng and Fatigue

American ginseng does not improve fatigue in multiple sclerosis: a randomized double-blind placebo-controlled crossover study.
This study examined the safety and efficacy of an escalating dose (100 mg, 200 mg, 400 mg/day) of American ginseng over 6 weeks in 56 MSers with fatigue. There were no serious adverse events but fatigue on ginsengwas not significantly different from fatigue on placebo.

Another Loooooooooooooong Post

In response to posts on EAE You wrote “Given that the risk factors for MS in humans are female gender, Vit D deficiency, infection with EBV, smoking, month of birth, how does the mouse model reflect these factors? In simple language it doesn’t, as the animal model has sufficient risks to develop disease. These risk factors combine to determine if one person or another will get MS...

BoTox in the Bladder reduces Incontinence

New Trial Efficacy and Safety of Onabotulinumtoxin on Urinary Incontinence Due to Neurogenic Detrusor Overactivity: A Randomised, Double-Blind, Placebo-Controlled Trial. Background: Neurogenic detrusor overactivity in the bladder frequently results in urinary incontinence that impairs quality of life. Objective:To assess the effects of onabotulinumtoxinA (BOTOX(®), Allergan, Inc.) on urinary...

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