ArchiveSeptember 2011

Dear Knitters,Here is the address to send your knitted cells to. Please label it as Dr Love’s Charcot Tapestry.c/o Professor G GiovannoniCentre for Neuroscience and Trauma,Blizard InstituteBarts and The London School of Medicine and Dentistry,4 Newark Street,London E1 2AT,United Kingdom. I am also planning to make a record of the production of the CT so if you would like to put a little...

Education: Targeting Progressive MS-Part V

If you can’t remember the story so far see: Part I , Part II (the Nerve Network), Part III (Nerve Plasticity), Part IV (Immune Attack) As part of the normal process of inflammation the body clears up the debris/damage caused during the fight to kill the infection by the white blood cells. This happens in MS after the demolition derby that causes the MS attack. People with relapsing-remitting MS...

Charcot Tapestry – the KNIT is ON!

Hello Knitters,Sorry it has taken me a while to get back to you but now it is official – the knit is on!The MS Society and the British Society of Immunology are supporting my efforts to make 4 tapestries depicitng what MS looks like under the microscope. If you would like to help here is the website with the kntting patterns to make different cells in the brains…. oligodendrocytes...

Education:Targeting Progressive MS-Part IV

Remember Part I , Part II (the Nerve Network), Part III (Nerve Plasticity) Todays’s Installment is revision, as you have seen some of this before in the Carpark. We don’t think there is necessarily any difference in this whether you have primary progressive or relapsing-remitting MS, althoiugh in progressiveMS the the following aspect is less pronounced. In health you have white blood cells...

Education. Drug-The Game. Time lines

Remember we were examining the drug development process, using Drug-The Game See Part I, Part II, Part III, Part IV, Back Again (read after part III) You asked for Time Lines about how long for useful drugs. It is not possible to predict, because each drug is different and the problems they encounter will be different. However “If I came up with the idea for the cure for MS tomorrow how...

Education: Demyelinated Nerves Transmit Slowly

As we have been building up a picture of the nerve impulse travelling on tube lines through undergound tunnels. We said that “When the myelin is removed from nerves as occurs in MS. The nerve impulse travels very slowly” So that you can see this I attach some videos So before you play videos below. At the bottom of the video is a picture of a nerve fibre (tube line) and the myelin...

Research: Alemtuzumab treatment of Interferon-Unresponsive MS

Fox EJ, Sullivan HC, Gazda SK, Mayer L, O’Donnell L, Melia K, Lake SL. A single-arm, open-label study of alemtuzumab in treatment-refractory patients with multiple sclerosis Eur J Neurol. 2011 [Epub ahead of print]. This is more of the same (good) news, with regard to Alemtuzumab. This un-controlled and unblinded study indicates that Alemtuzumab (an antibody that kills white blood cells)...

Education: Targeting Progressive MS-Part III

Remember Part I , Part II (theNerve Network).Today we need to discuss Nerve Plasticity. (Adaptation of Nerve Circuits).See Prof G’s Research Post today for a real example of this Imagine that in health that the nerve impulse (tube train) only has to travel between point A (Bond Street) and Point B (Tottenham Court Road) on the central line for things to work. Now because of MS, the central...

Education:Targeting Progressive MS-Part II

Remember Part I, left us at the Tube. To talk about progressive MS, we first need to get you thinking about- how things in the body are being affected so that we can build a final picture and then talk about solutions. The Nerve Network is made up of clusters of nerves that connect the brain with every bit of the body. Just imagine that this is an underground network with many tube lines each...

Education:Targeting Progressive MS-Part I

Whilst trying to explain how white blood cells enter the brain, using an analogy with a car park , you asked “whether cars (white blood cells) were central to the problem of progressive MS? “ Others asked “What is the problem in PPMS? “ Why don’t Current MS drugs work in PPMS?“ In the current series of (eight) short posts we will explore how Progressive MS...

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