It is good that you Bloggers posts things and maybe we can have a new feature
(Mouse)Doctoring the News!
This is what this Blog is about unravelling the Research News..Bad or Good..
(a) Allows us to reduce animal use (as these are normally a source for these cells).
(b) Have a large number of cells to be able to understand and study this process.
(c) We have large numbers of cells do that we can design assays to hunt for drugs that can promote the production and differentiation of myelin cells for treatments (as it would be too complicated to use the cocktails of chemicals that the researchers used in the study to do this in people with MS). The researchers showed evidence that this a possibility.
(d) It provides us with a source of cells that we can use to see it they can overcome the problems created by MS in experimental models. This study showed that the cells grown could make myelin in animals that naturally lack myelin. However, it is one thing to find ways to make myelin-forming cells, it is another thing to ask then to get into a scar and repair the myelin after the damage has been around for some time. However, addressing these questions will inform how best to apply the knowledge to MS
These are are all vital steps in helping to get drugs to help MS.
What this study does not say (the media might), is that now we can make millions of cells for treatment of MSers. This is only a step moving towards this goal.
We first need to see how this study in mice can be applied to making human cells. This is important because we know that not all of the factors that trigger this process in mice are used by human cells to do the same thing.
However it shows proof of principle that it can be done! So why can’t it be done for human cells?…No reason at all, it is just a question of hard slog, a bit of inspiration and finding the right combination of growth factors, inhibitors and stimulators. This study by the mousErs will no doubt stimulate the humanErs to help them find the answers for making human myelinating cells.
I have a great experiment ready waiting for this to happen.