ArchiveOctober 2011

Cataract and glaucoma in MS’ers

Epub ahead of print: Bazelier et al. Risk of cataract and glaucoma in patients with multiple sclerosis. Mult Scler. 2011 Oct 24. Background: The aim of the study was to evaluate whether MS is associated with risk of cataract or glaucoma (increased pressure in the eye).  Methods: The investigators conducted a population-based cohort study utilizing the UK General Practice...

MS presenting as a brain tumour

Kaeser et al. Tumefactive multiple sclerosis: an uncommon diagnostic challenge. J Chiropr Med. 2011 Mar;10(1):29-35.  OBJECTIVE: A case report describes a rare presentation of MS that was initially diagnosed as a peripheral nerve lesion. CLINICAL FEATURES: A 30-year-old woman presented with a complaint of a sudden right foot drop. MRI of the brain revealed a large mass in...

CSSVI News: Pro Data

Bastianello S, Romani A, Viselner G, Colli Tibaldi E, Giugni E, Altieri M, Cecconi P, Mendozzi L, Farina M, Mariani D, Galassi A, Quattrini C, Mancini M, Bresciamorra V, Lagace A, McDonald S, Bono G, Bergamaschi R. Chronic Cerebrospinal Venous Insufficiency in Multiple Sclerosis: Clinical Correlates from a Multicentre Study. BMC Neurol. 2011 Oct 26;11:132. BACKGROUND: Chronic cerebrospinal venous...

Results from the first trial of vitamin D for MS

A randomized trial of high-dose vitamin D2 in relapsing-remitting multiple sclerosis. Stein et al, Neurology, October 25, 2011 OBJECTIVE: Higher latitude, lower ultraviolet exposure, and lower serum 25-hydroxyvitamin D (25OHD) correlate with higher multiple sclerosis (MS) prevalence, relapse rate, and mortality. We therefore evaluated the effects of high-dose vitamin D2 (D2) in MS...

Research: Antibiotics and MS

Nørgaard M, Nielsen RB, Jacobsen JB, Gradus JL, Stenager E, Koch-Henriksen N, Lash TL, Sørensen HT. Use of Penicillin and Other Antibiotics and Risk of Multiple Sclerosis: A Population-based Case-Control Study. Am J Epidemiol. 2011;174:945-8. Background: A 2006 study from the United Kingdom (163 cases) found that penicillin use may decrease the risk of multiple sclerosis (MS). Methods: To confirm...

Science News: Microbes in the Gut Trigger MS?

Berer K, Mues M, Koutrolos M, Rasbi ZA, Boziki M, Johner C, Wekerle H, Krishnamoorthy G. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature. 2011 Oct 26. doi: 10.1038/nature10554. [Epub ahead of print] At ECTRIMS last week, there were a few Docs talking about digging in Pooh, looking for the Gold (Gut Flora) that teaches Us about the Trigger of MS...

Cortical lesions in MS

Sormani et al. Modeling the distribution of new MRI cortical lesions in multiple sclerosis longitudinal studies. PLoS One. 2011;6(10):e26712. Epub 2011 Oct 20. OBJECTIVE: Recent studies have shown the relevance of the cerebral grey matter involvement in MS. The number of new cortical lesions (CLs), detected by specific MRI sequences, has the potential to become a new research...

CCSVI: Un-supportive Data

Epub: Doepp F, Würfel JT, Pfueller CF, Valdueza JM, Petersen D, Paul F, Schreiber SJ. Venous drainage in multiple sclerosis: A combined MRI and ultrasound study. Neurology. 2011 Oct 26. [Epub ahead of print] “Our Data Contradictic the 100% prevalence of CCSVI criteria in MS”……..Another paper going with the tide! Will the Idea Drown? BACKGROUND: Chronic cerebrospinal venous...

Biogen-Idec announces results from the 2nd BG12 phase 3 trial

Biogen-Idec have announced positive top-line results from CONFIRM, the second of two pivotal phase 3 clinical trials designed to evaluate the effectiveness of the oral compound BG-12 (dimethyl fumarate) in RRMS’s.  BG-12 met the CONFIRM study’s primary endpoint by significantly reducing annualized relapse rate (ARR) by: 44% for twice daily (BID) dosing (p< 0.0001) and by 51%...

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