ArchiveNovember 2011

Team G

If you want another opertunity to see & meet members of Team G.The folks at Shift MS offered up Dr M&M on top tips for excersiceNow you can see Dr M&M give some Answers to the Questions PostedIf you don’t want to see, don’t press the links

Blog News: Silencing the Critics

Whilst trying to think about how to take the blog forward You wrote: “Why not cut the comments?“ Although this would limit time spent responding to posts and limit the tongue lashings that Prof G often gets, we felt that it does give you an oppertunity to ask questions. In addition they give us ideas for posts and your comments are often some of the most enligthening features, so we...

Basic Science: More clues for targets for remyelination

Chung AY et al. Microarray Screening for Genes Involved in Oligodendrocyte Differentiation in the Zebrafish CNS. Exp Neurobiol 2011 ;20:85-91. Within the vertebrate nervous system, myelination is required for the normal function of neurons (nerves) by facilitating the rapid conduction of action potentials (nerve impulses) along axons. Oligodendrocytes (myelin-forming cells) are glial cells which...

MS Research Day Tomorrow Calendar

It’s that time of year and soon January 2012 will be upon us. To help you rembember our MS Research Day on the 28th January, in Westminister Central London. You are all invited and it’s free…now that’s what I call a Christmas present. As treat I am doing Calender Mouse and will be shedding my usual white coat to put on some new outfits for our advent calendar that starts...

Research:Iron deposition elevated in MS

Habib CA et al. Assessing Abnormal Iron Content in the Deep Gray Matter of Patients with Multiple Sclerosis versus Healthy Controls. AJNR Am J Neuroradiol. 2011 Nov [Epub] BACKGROUND AND PURPOSE: It is well known that patients with MS tend to have abnormal iron deposition in and around the MS plaques in the brain. In this study, we quantify iron content in patients with MS and healthy...

Optic Neuritis: Testing for Neuromyelitis optica

Bojić et al. Role of NMO-Ig in Distinguishing the type of Optic Neuritis. Optom Vis Sci. 2011 Nov 17. [Epub ahead of print] PURPOSE: To emphasize the importance of neuromyelitis optica (NMO)-immunoglobulin G (IgG) antibodies testing in patients with typical optic neuritis (ON) refractory to steroid treatment. METHODS: Two patients were evaluated with ON refractory to steroid therapy and poor...

Research: BoTox for Bladder problems

Deffontaines-Rufin S et al. Botulinum Toxin A for the treatment of neurogenic detrusor overactivity in multiple sclerosis patients. Int Braz J Urol 2011 Sep;37:642-8 Purpose: Neurogenic detrusor overactivity (NDO. The muscle controlling bladder contraction is over active = urinary incontinence) is common in patients who suffer from multiple sclerosis (MS). When the usual pharmacological treatment...

Thanksgiving Cheer

Following the bombshell dropped by G about shutting the blog down, at your suggestion (see comments) that it’s time to give up EAE and become a RockGod …………………Again. I have dumped the lab coat and put on my outfit for a new evening job,….no it’s not a gimp suit. I bet you never guessed I play bass with Kiss under all that make-up...

Research:Immune attack of myelin may play a small influence,

Menge T, Lalive PH, von Budingen HC and Genain CP Conformational epitopes of myelin oligodendrocyte glycoprotein are targets of potentially pathogenic antibody responses in multiple sclerosis. Journal of Neuroinflammation 2011, 8:161 (17 November 2011) BACKGROUND:Myelin/oligodendrocyte glycoprotein (MOG) is a putative autoantigen in multiple sclerosis (MS). Establishing the pathological relevance...

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