ArchiveNovember 2011

Time to Kill the Mouse (Doctor)?

There are always questions about whether to use research animals to study human diseases some in favour some not so in favour Although I am a basic science fan, I’m not always in favour of mouse studies and so in the interests of variety I send you a link I got from one of the bloggers (great post may I add), which slates the poor lab mouse. I am not sure I always agree with the comments in...

Treatments: Me Toos

As drugs come out of their patent life(which prevents the manufacturer of the drug but other companies for about seventeen years from filing the patent)…..generic drugs(identical to the named brand) are made that are much cheaper. The first set of MS disease modifying therapies (DMT) are comming out of their patent life and so generics companies are ready to enter the market. Glaterimer...

If we are Cut, Do we not bleed?

THIS POSTING HAS BEEN GIVEN PRIME-TIME AGAIN AFTER 3 COMMENTS POSTED TODAY! WE WOULD BE INTERESTED IN YOUR THOUGHTS ON THEM AND ANY FEEDBACK!
Given your sometimes razor-sharp tongues. Did you know that Neurologists (clinicians) have evolved mechanisms to deal with Cutting Comments.

Science: Human Stem Cells Remyelinate a Rat

Pouya et al. Human Induced Pluripotent Stem Cells Differentiation into Oligodendrocyte Progenitors and Transplantation in a Rat Model of Optic Chiasm Demyelination PLoS ONE: 2011 10.1371/journal.pone.0027925 Background: This study aims to differentiate human induced pluripotent (grow into and cell type) stem cells (hiPSCs) into oligodendrocyte precursors and assess their recovery potential in a...

Blog News: Spam

It has come to my attention that Google operates a spam filter and this is taking out some of your
comments. Their content guide

So if you see it disappear then check out that the content (threats, Hate Speech) you maybe need to reword

P.S. Please do not post advertising links as these are typically removed.

Research: Identify of Oligoclonal bands

Yu et al. Intrathecally synthesized IgG in multiple sclerosis cerebrospinal fluid recognizes identical epitopes over time. J Neuroimmunol. 2011 Nov [Epub] CSF =cerebrospinal fluid Plasma =blood fluid Background: Intrathecal antibody production manifest as oligoclonal bands (OCBs) is a hallmark of multiple sclerosis (MS). Once present, OCBs can be detected in the cerebrospinal fluid that bathes...

Treatment: Tumour Risk with Mitoxantrone

Martinelli et al; For The Italian Mitoxantrone Group.Acute myeloid leukemia in Italian patients with multiple sclerosis treated with mitoxantrone.Neurology. 2011 Nov 9. [Epub]. OBJECTIVES: To evaluate the incidence and dose-dependency of mitoxantrone (MTX)-associated acute myelocytic leukemia (AML) in the network of Italian multiple sclerosis (MS) clinics. METHODS: We performed a multicenter...

Research: Effects of Dacluzimab in the CNS

Bielekova et al. Intrathecal effects of daclizumab treatment of multiple sclerosis.Neurology. 2011 Nov [Epub] OBJECTIVES: We previously reported that daclizumab, a humanized monoclonal antibody against CD25, reduced contrast-enhancing lesions (CEL) in patients with multiple sclerosis (MS), who were suboptimal responders to interferon-β and that this response correlated with expansion of...

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