Epub: Börnsen et al. Effect of Natalizumab on Circulating CD4(+) T-Cells in Multiple Sclerosis. PLoS One. 2012;7(11):e47578. doi: 10.1371/journal.pone.0047578. Epub 2012 Nov 30.In multiple sclerosis (MS), treatment with the monoclonal antibody natalizumab effectively reduces the formation of acute lesions in the central nervous system (CNS). Natalizumab binds the integrin very late antigen...
Exercise for MS
Tonight is New Years Eve, so some exercise for this evening.
Drink in Moderation and Don’t Drink and Drive.
Research Day 31
So this Concludes the House of Mouse Month. It is back to the boring white lab coat. Tomorrow brings another Year, with New Challenges and New Goals. It may have been a monstrous 2012 to some people and Not Others..Prof G is easily pleased, but lets hope we do better in 2013. Have a festive New Years Eve where every you are and Don’t drink too much Pop! If you...
Unrelated Blogger Comments New Years Eve
Sometimes you want to say something that is unrelated to the threads. This is a spot for You. Previous comments can be got at on the posts on the right of the main page.
We may be a bit slow responding over the festive period. Please be patient we will get back to you ASAP!
Research: clearing up myelin debris
Epub: Fernandez-Castaneda et al. Identification of the LDL Receptor-Related Protein-1 Interactome in Central Nervous System myelin suggests a role in the clearance of necrotic cell debris. J Biol Chem. 2012 Dec In the central nervous system (CNS), fast neuronal signals are facilitated by the oligodendrocyte-produced myelin sheath. Oligodendrocyte turnover or injury generates myelin...
Research Gender differences in MS
Epub: Rojas et al. Sex-related differences in atrophy and lesion load in multiple sclerosis patients. Neurologia. 2012 Dec 13. doi:pii: S0213-4853(12)00277-0. 10.1016/j.nrl.2012.10.008.INTRODUCTION: Previous studies showed gender-associated clinical and MRI differences in multiple sclerosis (MS) evolution. However, only few studies were done with non conventional MRI techniques and no one...
Research: Genetic pathways of MS
Epub: Song et al. Genome-wide pathway analysis of a genome-wide association study on multiple sclerosis. Mol Biol Rep. 2012 Dec 14. Aims: The aims of this study were to identify candidate single nucleotide polymorphisms (SNPs) and mechanisms of multiple sclerosis (MS) and to generate SNP to gene to pathway hypotheses. Methods: A MS genome-wide association study (GWAS) dataset that included...
Research Day 30
The stars of the Preclinical Research Work of TeamG Mr & Mrs BiozziMouse Guido Biozzi was a Brazilian working in the Institute Curie in Paris, France. In order to study the genetic regulation of the Immune response he made a cross between white Swiss mice. At each generation took the mice that produced either high or low amounts of antibody and bred them together so that...
Unrelated Blogger Comments 30
Sometimes you want to say something that is unrelated to the threads. This is a spot for You. Previous comments can be got at on the posts on the right of the main page.
We may be a bit slow responding over the festive period. Please be patient we will respond as soon as possible!
Research vessels at the centre of the lesion
Epub: Gaitán et al. Initial investigation of the blood-brain barrier in MS lesions at 7 tesla. Mult Scler. 2012 Dec 17. BACKGROUND: We previously described two dynamics of contrast enhancement in scans of active multiple sclerosis lesions: Medium-sized, early lesions enhance centrifugally, whereas larger, slightly older lesions enhance centripetally. Due to technical limitations, our previous...