Research: A microscope reveals more than a magnifying glass. MRI imaging

Epub ahead of print: Sinnecker et al. Multiple Sclerosis Lesions and Irreversible Brain Tissue Damage: A Comparative Ultrahigh-Field Strength Magnetic Resonance Imaging Study. Arch Neurol. 2012 Feb 20.

BACKGROUND: In current clinical practice, T2-weighted magnetic resonance imaging (MRI) is commonly applied to quantify the accumulated multiple sclerosis (MS) lesion load, whereas T1-weighted sequences are used to differentiate oedema (swelling), blood-brain barrier breakdown by contrast enhancement, and irreversible brain tissue damage (commonly called “black holes” owing to the loss of signal intensity in T1-weighted sequences). Black holes are histopathologically associated with axonal loss and severe tissue destruction. In addition, double inversion recovery techniques were developed to improve the sensitivity to cortical (in the grey matter) lesions.

OBJECTIVE: To demonstrate the potential of ultrahigh-field 3-dimensional T1 weighted imaging using magnetization-prepared rapid acquisition and multiple gradient-echoes (MPRAGE) to detect and characterize white and gray matter pathology in MS.

METHODS: Twenty patients with relapsing-remitting MS and 14 healthy controls underwent 7-Telsa brain MRI, using a 24-channel receive head coil, and a subgroup of 18 patients with relapsing-remitting MS also underwent 1.5-T brain MRI. The imaging protocol included 2-dimensional T2-weighted fast low-angle shot (FLASH) and turbo inversion recovery magnitude (TIRM) sequences. For 3-dimensional T1-weighted imaging, the MPRAGE sequence was used. Each sequence was initially examined independently in separate analyses by an investigator blinded to all other data. In a second study, all detected lesions were retrospectively analyzed in a side-by-side comparison of all sequences.

RESULTS: By use of 7-Telsa, T2-weighted FLASH imaging, 604 cerebral (brain) lesions were detected in the patients with relapsing-remitting MS (mean, 30.2 lesions per patient [range, 2-107 lesions per patient]), but none were detected in healthy controls.

Cortical (grey matter) pathology was visible in 10 patients (6 cortical lesions and 37 leucocortical lesions). Within the 7-T acquisitions, each lesion detected at T2-weighted sequences and/or double inversion recovery sequences was also clearly delineated on corresponding MPRAGE sequences in side-by-side analysis. However, at 1.5 T, the MPRAGE images depicted only 452 of 561 lesions visualized in T2-weighted sequences and/or double inversion recovery sequences. In contrast, when analyzing each sequence separately, we found that the 7-T MPRAGE depicted more lesions than the 7-T FLASH (728 lesions vs 584 lesions), and almost twice as many as the 1.5-T MPRAGE (399 lesions). The 7-T MPRAGE also improved the detection of cortical and leukocortical lesions (15 lesions vs 58 lesions).

CONCLUSIONS: At ultrahigh-field strength, T1-weighted MPRAGE is highly sensitive in detecting MS plaques within the white and the gray brain parenchyma. Our results indicate structural damage beyond demyelination in every lesion depicted, which is in accordance with postmortem histopathological studies. The 7-T MPRAGE clearly delineated every cortical lesion that was visualized by any other MRI sequence at 1.5 or 7 T.

If you look through a microscope you will see more than using a magnifying glass and so it is not surprising that with a 7 tesla machine you see more than with the standard 1.5 telsa or the more high-powered 3 telsa machines. However if you look through a microscope you still often see more than can be see using MRI, the advantage of the latter is that is an imaging tool for the living. With this high powered imaaging it will show us that the disease is even more active than previously shown as it will detect more lesions comming and going

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    Capiche dum dum?

    There must be some control on the quality of the post (and most importantly the quality of the comments!)

    Let's focus on quality rather than quantity. . . otherwise this exceptional blog becomes like everything else.

  • Just because you don't like it, doesn't mean others don't either!
    For some, variety is the spice of life and we learn much when venturing out of our respective comfort zones.

  • "Our results indicate structural damage beyond demyelination in every lesion depicted, which is in accordance with postmortem histopathological studies."

    I thought this was interesting. Could you say more about the other kinds of structural damage?

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