ArchiveMarch 2012

Research: Brain Pathways

A network of hundreds of interconnected and microscopically identifiable areas in the human cerebral cortex controls cognition, perception, and behaviour. Each area covers up to 40 square cm (40cm x 40cm) of the cortical (outside layer of the brain) surface and consists of up to 750 million nerve cells. The architecture which is the spatial distribution, number, size, and shape of nerve...

Research: MRI and Symptoms

Hackmack K, Weygandt M, Wuerfel J, Pfueller CF, Bellmann-Strobl J, Paul F, Haynes JD. Can we overcome the ‘clinico-radiological paradox’ in multiple sclerosis?J Neurol. 2012 Mar 24. [Epub ahead of print] The association between common neuroradiological markers of multiple sclerosis (MS) and clinical disability is weak, a phenomenon known as the clinico-radiological paradox. Here, we...

Research: To Gadolinium or Not to Gadolinium. That is the question

Shinohara RT, Goldsmith J, Mateen FJ, Crainiceanu C, Reich DS. Predicting Breakdown of the Blood-Brain Barrier in Multiple Sclerosis without Contrast Agents.AJNR Am J Neuroradiol. 2012 Mar 22. [Epub ahead of print] BACKGROUND AND PURPOSE:  Disruption of the BBB in MS is associated with the development of new lesions and clinical relapses and signifies the presence of active inflammation. It...

Research:Genetics of Progression

Martinelli-Boneschi et al. A genome-wide association study in progressive multiple sclerosis.Mult Scler. 2012 Mar 28. [Epub ahead of print]  Background: The role played by genetic factors in influencing the clinical course of multiple sclerosis (MS) is not yet well established. Objective: We aimed to identify genetic variants associated with progressive MS (PrMS). Methods: We...

Research: Endogenous retrovirus and MS

Perron et al. Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease. Mult Scler. 2012 Mar 28. [Epub ahead of print]  Background: The envelope protein from multiple sclerosis (MS) associated retroviral element (MSRV), a member of the Human Endogenous Retroviral family ‘W’ (HERV-W), induces...

Research: Virus in the CSF

Kułakowska et al. Multiplexing analysis of the polyspecific intrathecal immune response in multiple sclerosis.Methods. 2012 Mar 16. [Epub ahead of print] Intrathecal synthesis of the antibodies specific to neurotrofic viruses: measles (M), rubella (R), Varicella-Zoster (Z), and/or H. simplex (H), known as “MRZH-reaction” plays important diagnostic role in multiple sclerosis (MS)...

Voxelwise MRI and disability

Epub ahead of print:  Wybrecht et al. Voxelwise analysis of conventional magnetic resonance imaging to predict future disability in early relapsing-remitting multiple sclerosis. Mult Scler. 2012 Mar 28.  Background: The ability of conventional MRI to predict subsequent physical disability and cognitive deterioration after a clinically isolated syndrome (CIS) is weak...

Neutralizing antibodies to natalizumab

Epub ahead of print:  Jensen et al. Prediction of antibody persistency from antibody titres to natalizumab.  Mult Scler. 2012 Mar 28. Background: In a subgroup of MSers natalizumab therapy causes generation of anti-natalizumab antibodies that may be transient or persistent. It is recommended to discontinue natalizumab therapy in persistently antibody-positive patients. Objective:...

Research: B cells Abit late Now

Mann MK, Ray A, Basu S, Karp CL, Dittel BN. Pathogenic and regulatory roles for B cells in experimental autoimmune encephalomyelitis. Autoimmunity. 2012 Mar 26. [Epub ahead of print] A dual role of B cells in experimental autoimmune encephalomyelitis (EAE), the animal model of the human autoimmune disease multiple sclerosis (MS), has been established. In the first role, B cells contribute to the...

Research: Animal Studies Suggest that CCSVI is a Non-Starter for MS

Atkinson W et al. Ligation of the Jugular Veins Does Not Result in Brain Inflammation or Demyelination in Mice PLoS ONE 7(3): e33671. doi:10.1371/journal.pone.0033671 An alternative hypothesis has been proposed implicating chronic cerebrospinal venous insufficiency (CCSVI) as a potential cause of multiple sclerosis (MS). We aimed to evaluate the validity of this hypothesis in a controlled animal...

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