ArchiveMarch 2012

Research: Brain Pathways

A network of hundreds of interconnected and microscopically identifiable areas in the human cerebral cortex controls cognition, perception, and behaviour. Each area covers up to 40 square cm (40cm x 40cm) of the cortical (outside layer of the brain) surface and consists of up to 750 million nerve cells. The architecture which is the spatial distribution, number, size, and shape of nerve...

Research: MRI and Symptoms

Hackmack K, Weygandt M, Wuerfel J, Pfueller CF, Bellmann-Strobl J, Paul F, Haynes JD. Can we overcome the ‘clinico-radiological paradox’ in multiple sclerosis?J Neurol. 2012 Mar 24. [Epub ahead of print] The association between common neuroradiological markers of multiple sclerosis (MS) and clinical disability is weak, a phenomenon known as the clinico-radiological paradox. Here, we...

Research: To Gadolinium or Not to Gadolinium. That is the question

Shinohara RT, Goldsmith J, Mateen FJ, Crainiceanu C, Reich DS. Predicting Breakdown of the Blood-Brain Barrier in Multiple Sclerosis without Contrast Agents.AJNR Am J Neuroradiol. 2012 Mar 22. [Epub ahead of print] BACKGROUND AND PURPOSE:  Disruption of the BBB in MS is associated with the development of new lesions and clinical relapses and signifies the presence of active inflammation. It...

Research:Genetics of Progression

Martinelli-Boneschi et al. A genome-wide association study in progressive multiple sclerosis.Mult Scler. 2012 Mar 28. [Epub ahead of print]  Background: The role played by genetic factors in influencing the clinical course of multiple sclerosis (MS) is not yet well established. Objective: We aimed to identify genetic variants associated with progressive MS (PrMS). Methods: We...

Research: Endogenous retrovirus and MS

Perron et al. Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease. Mult Scler. 2012 Mar 28. [Epub ahead of print]  Background: The envelope protein from multiple sclerosis (MS) associated retroviral element (MSRV), a member of the Human Endogenous Retroviral family ‘W’ (HERV-W), induces...

Research: Virus in the CSF

Kułakowska et al. Multiplexing analysis of the polyspecific intrathecal immune response in multiple sclerosis.Methods. 2012 Mar 16. [Epub ahead of print] Intrathecal synthesis of the antibodies specific to neurotrofic viruses: measles (M), rubella (R), Varicella-Zoster (Z), and/or H. simplex (H), known as “MRZH-reaction” plays important diagnostic role in multiple sclerosis (MS)...

Research: B cells Abit late Now

Mann MK, Ray A, Basu S, Karp CL, Dittel BN. Pathogenic and regulatory roles for B cells in experimental autoimmune encephalomyelitis. Autoimmunity. 2012 Mar 26. [Epub ahead of print] A dual role of B cells in experimental autoimmune encephalomyelitis (EAE), the animal model of the human autoimmune disease multiple sclerosis (MS), has been established. In the first role, B cells contribute to the...

Research: Animal Studies Suggest that CCSVI is a Non-Starter for MS

Atkinson W et al. Ligation of the Jugular Veins Does Not Result in Brain Inflammation or Demyelination in Mice PLoS ONE 7(3): e33671. doi:10.1371/journal.pone.0033671 An alternative hypothesis has been proposed implicating chronic cerebrospinal venous insufficiency (CCSVI) as a potential cause of multiple sclerosis (MS). We aimed to evaluate the validity of this hypothesis in a controlled animal...

March:Unrelated blogger comments 2

Sometimes you what to say something that is unrelated to the threads.
This is a spot for You. (This post may move around abit)
If you do not see you comment appear, it has been spammed by Google. There is an offensive word, term in there, reword and it should repost

Research: Remyelination and Galanin.. another way

Zhang et al. Galanin Transgenic Mice with Elevated Circulating Galanin Levels Alleviate Demyelination in a Cuprizone-Induced MS Mouse Model.PLoS One. 2012;7(3):e33901. Epub 2012 Mar 19. MS is a demyelinating autoimmune disease of the central nervous system (CNS) with a presumed autoimmune etiology. Approved treatments for MS are immunoregulatory and are able to reduce the inflammatory components...

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