“This study shows that an MRI marker of structural integrity can predict disability progression in MS’ers in the future. This implies that MS’ers with damage are more likely to progress in the future; i.e. damage be-gets damage. This supports many other clinical and MRI studies in MS. MS’ers who already have acquired damage, clinically or sub-clinically on MRI, are the ones who will progress more in the future.”
MATERIALS AND METHODS: 54 patients with MS (87% under immunomodulatory therapy, baseline and follow-up at a median of 12 months).
RESULTS: At both time points, ADC (diffusivity) histogram analysis provided robust predictors of the MS functional composite scores (R-squared = 0.58, P < .001)*, incorporated cognition and fine-motor skill subscores, and EDSS scores.
CONCLUSIONS: Diffusion histogram analysis provided stable surrogates of disability in MS and proved sensitive for monitoring disease progression during a median of 12 months. Advanced neuroaxonal pathology at baseline was indicative of an increased risk for sustained progression during a median of 12 months, independent of intercurrent relapses.