Research: Brain Shrinkage

Riccitelli et al. Mapping regional grey and white matter atrophy in relapsing-remitting multiple sclerosis.Mult Scler. 2012 Mar 15. [Epub ahead of print]

Objective: We aimed to investigate the regional distribution of grey matter (GM) and white matter (WM) atrophy in patients with relapsing-remitting (RR) MS and their relationship with gender, clinical findings, and T2 lesions.

Methods: Clinical and magnetic resonance imaging assessments were obtained from 78 patients with RRMS and 88 controls. GM and WM atrophy were estimated using voxel-based morphometry (SPM8).

Results: Patients with RRMS experienced atrophy of the deep GM nuclei, and several cortical regions mainly located in the fronto-parietal lobes. WM atrophy involved posterior (at the back) regions of the brain, including the cerebellum and brainstem. Compared with men, affected women showed atrophy of several WM tracts, while gender did not impact GM atrophy. Disease duration > 5 years was associated with atrophy of the thalami and inferior frontal gyrus, while WM atrophy was already prominent in patients with disease duration ≤ 5 years. Expanded Disability Status Scale score > 3.0 was associated with diffuse WM atrophy (shrinkage) and basal ganglia and precentral gyrus atrophy. T2 lesions were marginally associated to focal atrophy.

Discussion: In RRMS, GM and WM atrophy have distinct patterns of regional distribution, with a sparing of GM infratentorial regions. Gender, disease duration and disability affect differently the topography of GM/WM atrophy, while T2 lesions play a modest role.

This is a descriptive study, follow the links to see what each bit of the brain does. This study reports on brain shrinkage during MS. The problem of using MRI to assess shrinkage is that this can be masked by fluid accumulation.

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  • "GM and WM atrophy have distinct patterns of regional distribution, with a sparing of GM infratentorial regions"

    How can pattern of any kind be consistent with random autoimmune or random viral attack? Do you see patterns in EAE or viral models also?

  • (1) How do lymphocytes choose the entry point within the cerebral and spinal vascular system?

    (2) A link maybe? Or a title?

  • (1) Adhesion molecules and counter receptors eg. CD49d and CD105

    (2) I know there is one this year even. Do your homework

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