ArchiveApril 2012

April 3 Unrelated blogger comments

April Comments from the Unrelated blogger link have been moved here 30 comments: Anonymous said… Prof. Giovanonni, I would like to know at what point does a patient with severe symptoms of PPMS get admitted to hospital for treatment or recovery in the UK? I am familiar with a case where there might be a danger of irreparable axonal loss as treatment is being delayed (for reasons unknown to...

Research: Will CCSVIers modify their views in face of negative information?

TO ALL THE PEOPLE WHO ARE TROLLING US, PLEASE STOP!!! You spoil the site for people who are genuinely interested.  Posts are Being Moderated (Read) before going Public, This is not Censorship, Just Rubbish Removal (Thats Gargbage Collection in American). Please be Patient  Posts, Even negative Ones Will Appear Eventually, Well we have been talking about abstracts at the AAN this week...

Education: Espresso pathology-Grey Matters

More Espresso pathology (click) For many years MS was though of as a white matter disease, this was because MRI could not see grey matter lesions and importantly this was because that is what pathologists were telling us. However they must have had their eyes closed because you can see some of them with the naked eye and they have been reported in the literature many years ago.  But if you...

Research: Tysabri Works after you have been on other DMT

Lanzillo R et al Natalizumab is effective in multiple sclerosis patients switching from other disease modifying therapies in clinical practice.Neurol Sci. 2012 Apr 22. [Epub ahead of print] Natalizumab is one option for multiple sclerosis patients responding poorly to classical immunomodulators, but pilot studies did not point to its effectiveness as a second-line therapy. Aim of this study was...

TROLLS ARE UNWELCOME

TO ALL THE PEOPLE WHO ARE TROLLING US, PLEASE STOP!!! You spoil the site for people who are genuinely interested. For the Time Being All Posts are Being Moderated,  This does not mean Censored! All the Insulting, Rubbish  Will be Dumped in the Spam Bin Please be Patient  Sensible, Constructive Even if Negative Comments  Will Appear Eventually,  A Behavioural...

Education: The Th1 v Th2 paradigmn

The T cells can be divided in killing cells (CD8) that are programmed to kill viruses inside the cell and CD4 T helper (Th) cells. These helper produce growth factors that help B cells to make antibodies or growth factors to help macrophages kill pathogens (disease causing agents).  Th1 are designed to get rid of intracellular (inside the cell) parasites, bacteria, virus, Th2 are designed to...

How do we know about something before publication:WORMS

As we have talked about the publication process in the past, as the American Academy of Neurologists meeting is occurring this week it is easy to see how journalists can find subjects to post many months or years before the publication appears in the scientific literature. You can easily see what’s on offer (link), so I don’t have to go to New Orleans. Some studies may never materialise because...

Research: Benign MS is not Benign

Another Abstract from the AAN    [P01.138] Long Term Evolution of “Benign” Multiple Sclerosis Patients in the London Ontario Database Antonio Scalfari,  Anneke Neuhaus, Martin Daumer, Paolo Muraro, George Ebers. OBJECTIVE: Using conversion to secondary progressive (SP) multiple sclerosis (MS) as cutoff event for selecting patients with benign course, we tested which baseline...

Research:Sex and MS

Following our post from the weekend I thought I would have a look at studies of MS and sexual problems. The amount of information is surprisingly limited for an issue that is pretty common, as can be seen from the posts, and obviously affects quality of life. I have pulled a few papers from different countries, which lacks a UK component.. Are we Brits incapable of talking about sex, well for...

Research:Internet based outcome measures

Moss-Morris R et al. A pilot randomised controlled trial of an Internet-based cognitive behavioural therapy self-management programme (MS Invigor8) for multiple sclerosis fatigue.Behav Res Ther. Epub The majority of people affected by Multiple Sclerosis (paMS) experience severe and disabling fatigue. A recent randomised controlled trial (RCT) showed that cognitive behaviour therapy with a...

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