Research: Vitamin D supplementation

R
Epub: Allen et al. A pilot study of the immunological effects of high-dose vitamin D in healthy volunteers. Mult Scler. 2012 Mar 28.


Although
vitamin D deficiency is considered an environmental factor in MS, the immunological and clinical effects of vitamin D
supplementation remain unclear. We performed a pilot study of the
immunomodulatory effects of vitamin D in healthy individuals (n=4), who
took 5000-10,000 IU/day of vitamin D over 15 weeks. After 15 weeks of
vitamin D supplementation, serum 25(OH) vitamin D levels rose
significantly from baseline, with a corresponding increase in IL-10
production by peripheral blood mononuclear cells and a reduced frequency
of Th17 cells. These data provide a strong rationale for randomised
trials to assess the clinical effects of vitamin D supplementation in
MS.


“After 15 weeks of supplementation vitamin D levels rose, well I hope so otherwise there would be zero point. Interleukin-10 an immunomodulatory cytokine (immune messenger that cells use to communicate we each other) was reduced as was Th17 cells,
which are a type of white blood cell thought to mediate autoimmunity.
While these changes may be in the right direction an analysis
of FOUR people is too low to be meaningful. It
could all have occurred by chance and is not good science; generally these studies need to be done on ~15-20 people. 

About the author

Prof G

Professor of Neurology, Barts & The London. MS & Preventive Neurology thinker, blogger, runner, vegetable gardener, husband, father, cook and wine & food lover.

2 comments

  • I am so confused at the vitamin D2and D3 debate.

    I take 4000IU of vit D2 yet there are some people arguing it will not help me because it's the wrong type of vitamin D.

    D3 is more expensive than D2.

  • Re: "I take 4000IU of vit D2 yet there are some people arguing it will not help me because it's the wrong type of vitamin D."

    vD2 is slightly less potent than vD3; taking vD is more important than not taking it so do what you can. If you have concerns about the dose get your blood vD levels checked after 6 weeks.

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