ArchiveMay 2012

Survey: Trial for Progressive MSers

With the sad failure of the CUPID trial for Progressive MSers, we can’t just wait for 3-5 years for each trial to occur. We need novel designs that can speed up this process! With this in mind please take the time to do the “MS lumbar puncture” survey, which may help get one such design off the ground (Click on Top left) or here for the link to the study design. It does not...

Research: monitoring brain shrinkage

Shiee et al. Revisiting brain atrophy and its relationship to disability in multiple sclerosis. PLoS One. 2012;7(5):e37049.  BACKGROUND: Brain atrophy (shrinkage) is a well-accepted imaging biomarker of multiple sclerosis (MS) that partially correlates with both physical disability and cognitive impairment. METHODOLOGY/PRINCIPAL FINDINGS: Based on MRI scans of 60 MS cases and 37 healthy...

Research: CCSVI Monthly- May

Zivadinov R et al. Association Between Conventional Brain MR Imaging and Chronic Cerebrospinal Venous Insufficiency in Multiple Sclerosis. AJNR Am J Neuroradiol. 2012 May 10. [Epub ahead of print] BACKGROUND AND PURPOSE: CCSVI has been reported to occur at high frequency in MS. Its significance in relation to MR imaging parameters also needs to be determined, both in patients with MS and HCs...

Education: How is a T cell stimulated

We have talked about the major histocompatibility complex (MHC) and how this is gives us our identities and allows use to distinguish ourselves from invaders into the body. The  T cell has a molecule that allows it to see its target. This is called the T cell receptor. There are many variants and this allows them to recognise alot (a billion billion) of targets These come together so the T...

Research: stopping progression – neuroprotection on its way with erythropoietin

Epub: Sühs KW et al. A randomized, double-blind, phase II study on erythropoietin in optic neuritis Annal Neurol. 28 Feb 2012. Objectives: Based on findings in animal models of autoimmune optic nerve inflammation, we have assessed the safety and efficacy of erythropoietin in patients presenting with a first episode of optic neuritis. “erythropoietin is a hormone produced by the kidney that...

Research: Nerve regeneration is more in MS than after brain trauma

Epub: Schirmer et al. Neuroaxonal regeneration is more pronounced in early multiple sclerosis than in traumatic brain injury lesions. Brain Pathol. 2012 May 21.  The extent of irreversible neuroaxonal (nerve cells and their processes) damage is the key determinant of permanent disability in traumatic and inflammatory conditions of the central nervous system (CNS). Structural damage is...

Research:Prineas lesion was it NMO?

Point-of-view: Prineas & Parratt. Oligodendrocytes and the early multiple sclerosis lesion J Neurol: 24 APR 2012. There is little agreement amongst neuropathologists regarding the timing and nature of oligodendrocyte loss in MS. The oligodendrocyte is the cell that makes myelin or the insulation around nerve fibres. This review describes changes that accompany acute...

Research: T regulatory or T-reg cells

Epub: Bjerg et al. Altered frequency of T regulatory cells is associated with disability status in relapsing-remitting multiple sclerosis patients. J Neuroimmunol. 2012 May 16. Regulation of the immune system may be part of the pathogenesis of relapsing-remitting MS (RRMS). In this study, the investigators demonstrate a dichotomy within the frequency of a regulatory white blood, cells called T...

Research: viral infection and MS..best evidence is with EBV

Zaadstra et al.  Selective association of multiple sclerosis with infectious mononucleosis. Mult Scler. 2008;14(3):307-13. Previous studies have suggested an association between MS and infectious mononucleosis (IM) but data on the exact strength of this association or its selectivity have been conflicting. In this study the investigators evaluated the association between MS and a...

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