ArchiveMay 2012

ABN talk on MS services

The following are the slides from my talk that I gave today at the Association of British Neurologists (ABN) meeting in Brighton. The purpose of the meeting was to challenge consultant neurologists to  think about the services they provide MSers. I hope I achieved something. 

ABN MS Services

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Survey: Trial for Progressive MSers

With the sad failure of the CUPID trial for Progressive MSers, we can’t just wait for 3-5 years for each trial to occur. We need novel designs that can speed up this process! With this in mind please take the time to do the “MS lumbar puncture” survey, which may help get one such design off the ground (Click on Top left) or here for the link to the study design. It does not...

Research: monitoring brain shrinkage

Shiee et al. Revisiting brain atrophy and its relationship to disability in multiple sclerosis. PLoS One. 2012;7(5):e37049.  BACKGROUND: Brain atrophy (shrinkage) is a well-accepted imaging biomarker of multiple sclerosis (MS) that partially correlates with both physical disability and cognitive impairment. METHODOLOGY/PRINCIPAL FINDINGS: Based on MRI scans of 60 MS cases and 37 healthy...

Research: the stigma of MS

Epub: Molina et al. The Stigma Scale for Chronic Illnesses 8-Item Version (SSCI-8): Development, Validation and Use Across Neurological Conditions.Int J Behav Med. 2012 May BACKGROUND: Although the impact of stigma has been highlighted for epileptic populations, the experiences of people living with other neurological conditions have been less well studied. PURPOSE: In order to promote...

Research: CCSVI Monthly- May

Zivadinov R et al. Association Between Conventional Brain MR Imaging and Chronic Cerebrospinal Venous Insufficiency in Multiple Sclerosis. AJNR Am J Neuroradiol. 2012 May 10. [Epub ahead of print] BACKGROUND AND PURPOSE: CCSVI has been reported to occur at high frequency in MS. Its significance in relation to MR imaging parameters also needs to be determined, both in patients with MS and HCs...

Research: giving the diagnosis of MS

Epub: Martinelli et al. Disclosing the diagnosis of multiple sclerosis: The Profile Project. J Neurol. 2012 May 26. Communicating the diagnosis of MS is a challenging task, often undertaken with discomfort by most neurologists. Only a few studies have investigated MSers satisfaction with timing and way of receiving the diagnosis, but surveys regarding physicians’ attitude towards diagnosis...

Research: Is NMO triggered by a bacteria

Varrin-Doyer et al. Aquaporin-4-specific T cells in neuromyelitis optica exhibit a Th17 bias and recognize Clostridium ABC transporter. Annal Neurol. 25 MAY 2012. Objective: Aquaporin-4 (AQP4)-specific autoantibodies in neuromyelitis optica (NMO) are IgG1, a T cell-dependent Ig subclass, indicating AQP4-specific T cells participate in NMO pathogenesis. The investigators’ goal was to...

Education: How is a T cell stimulated

We have talked about the major histocompatibility complex (MHC) and how this is gives us our identities and allows use to distinguish ourselves from invaders into the body. The  T cell has a molecule that allows it to see its target. This is called the T cell receptor. There are many variants and this allows them to recognise alot (a billion billion) of targets These come together so the T...

Cannabinoid Use in Progressive Inflammatory brain Disease (CUPID) study

Introduction: The CUPID study investigated the usefulness of cannabinoids (chemical compounds found in the cannabis plant) or THC slowing progression in MS. Aims: The study set out to investigate the following:- 1. Does THC have any value in slowing progressive MS over a three year period? 2. Is THC safe over a three year period? 3. Can clinical trial design and conduct be improved by using newer...

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