ArchiveMay 2012

Research:Restless Leg syndrome

Vávrová J et al. Restless legs syndrome in Czech patients with multiple sclerosis: An epidemiological and genetic study.Sleep Med. 2012 May 18. [Epub ahead of print] BACKGROUND: Restless legs syndrome (RLS) is a frequent neurological disorder which is presented in idiopathic and secondary form. Idiopathic RLS is associated with common genetic variants in four chromosomal regions. Recently...

Research:EBV in Animal Models

Chang RA, Miller SD, Longnecker R Epstein-Barr virus latent membrane protein 2A exacerbates experimental autoimmune encephalomyelitis and enhances antigen presentation function. Sci Rep. 2012;2:353. Epub 2012 Apr 3 Multiple sclerosis (MS) is an inflammatory, autoimmune disease of the central nervous system. The cause of MS is still unknown but epidemiological and immunological studies have...

Research: Vitamin D in Mice

Wang D et al. Development of experimental autoimmune encephalomyelitis (EAE) in mice requires vitamin D and the vitamin D receptor. Proc Natl Acad Sci U S A. 2012 May 16. [Epub ahead of print] The development of experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis, has been studied in mice that were (i) vitamin D-deficient, (ii) minus the vitamin D receptor, (iii) minus...

Research: Sex Ratio with MS increasing in Women

Sex ratio of multiple sclerosis in Canada: a longitudinal study. Orton SM, Herrera BM, Yee IM, Valdar W, Ramagopalan SV, Sadovnick AD, Ebers GC; Canadian Collaborative Study Group. Lancet Neurol. 2006 Nov;5(11):932-6. BACKGROUND: Incidence of multiple sclerosis is thought to be increasing, but this notion has been difficult to substantiate. In a longitudinal population-based dataset of patients...

Research Stability of JC Virus antibody responses

Antonsson A et al. Prevalence and stability of antibodies to the BK and JC polyomaviruses: a long-term longitudinal study of Australians.J Gen Virol. 2010l;91:1849-53. Serology has been used to indicate past infection by the human polyomaviruses BK virus (BKV) and JC virus (JCV), because the site of primary infection is not established fully. Little is known about BKV and JCV antibody stability...

Research:MS in Women

Epub: Kotzamani et al. Rising incidence of multiple sclerosis in females associated with urbanization. Neurology. 2012 May 16.  OBJECTIVE: To design and perform a case-control study of multiple sclerosis (MS) in Crete, an island of 0.6 million people, that has experienced profound socioeconomic changes in recent decades. METHODS: All MS cases occurring on Crete...

Research: More Stem Cell Hype or is it the Real Deal?

 Bai L et al. Hepatocyte growth factor mediates mesenchymal stem cell–induced recovery in multiple sclerosis models Nature Neuroscience (2012) doi:10.1038/nn.3109 [Epub May] Mesenchymal stem cells (MSCs) have emerged as a potential therapy for a range of neural insults. In animal models of multiple sclerosis, an autoimmune disease that targets oligodendrocytes and myelin, treatment with...

Research: JC Virus in Urine

Laroni A et al. Urinary JCV-DNA Testing during Natalizumab Treatment May Increase Accuracy of PML Risk Stratification.J Neuroimmune Pharmacol. 2012 May 16. [Epub ahead of print] The risk of progressive multifocal leukoencephalopathy (PML) in patients treated with natalizumab for multiple sclerosis (MS) is a serious concern. The presence of anti-JC virus antibodies is a risk factor...

Research: JC Virus seropositivity in MSers

Trampe AK et al. Anti-JC virus antibodies in a large German natalizumab-treated multiple sclerosis cohort. Neurology. 2012 May 16. [Epub ahead of print] OBJECTIVE: To investigate the rate of seropositivity of anti-JC virus (JCV) antibodies in a German multiple sclerosis (MS) cohort treated with natalizumab in the postmarketing setting and to assess anti-JCV serostatus in samples obtained before...

Research: Facal Pain Relief and Surgery

Epub: Mallory et al. Outcomes after Percutaneous Surgery for Patients with Multiple Sclerosis Related Trigeminal Neuralgia. Neurosurgery. 2012 May 15. BACKGROUND: Approximately 1-2 percent of patients with multiple sclerosis develop trigeminal neuralgia (TN). Percutaneous surgery is commonly performed in medically refractory cases. OBJECTIVE: To analyze the pain outcomes and complications...

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