ArchiveMay 2012

Research: Axonal Loss and disability

It is not possible to determine exactly how many nerves can be lost before their absence is noted, but this will depend on which areas of the CNS are affected. For MS we can only link precise nerve content to disability at post-mortem so it hard to say. However imaging studies suggest that there may be loss of 1% a year compared to 0.1% with normal aging.  Bjartmar C, Kidd G, Mörk S, Rudick...

How is MS neuropathology reflected in MRIs?

Lancet Neurol. 2012 Apr;11(4):349-360. Epub 2012 Mar 19. Association between pathological and MRIfindings in multiple sclerosis. Filippi M, et al; for the Attendees of theCorrelation between Pathological MRI findings in MS workshop. The identification of pathological processes that could be targeted by therapeutic interventions is a major goal of research into MS. Pathological assessment is...

Research: Brain shape changes in MS

Sigrili D et al. Shape Analysis of the Corpus Callosum and Cerebellum in Female MS Patients with Different Clinical Phenotypes. Anat Rec  2012 May 14. doi: 10.1002/ar.22493. The aim of this study was to investigate the shape differences in the corpus callosum (CC) and cerebellum of female relapsing-remitting multiple sclerosis (RRMS) and secondary progressive multiple sclerosis (SPMS)...

Research: Corpus Callosum and brain function

Llufriu et al. S. Influence of Corpus Callosum Damage on Cognition and Physical Disability in Multiple Sclerosis: A Multimodal Study. PLoS One. 2012;7(5):e37167. Epub 2012 May 14. BACKGROUND:Corpus callosum (CC) is a common target for multiple sclerosis (MS) pathology. We investigated the influence of CC damage on physical disability and cognitive dysfunction using a multimodal approach. METHODS:...

Research: Assessing whether you are likely to Fall

Prosperini L et al. The Diagnostic Accuracy of Static Posturography in Predicting Accidental Falls in People With Multiple Sclerosis. Neurorehabil Neural Repair. 2012 May 15. [Epub ahead of print] BACKGROUND: Quantitative posturography has been reported as a reliable tool to measure balance in people with multiple sclerosis (MS). However, data on its diagnostic accuracy in predicting the...

Education: What is the HLA?

The HLA means the Human Leucocyte antigen (HLA) which is also known as the major histocompatilibilty complex (MHC). This region coded on chromosome 6 determines the individuality of each of us.  This is very differnt between each individual because there are alot of different variants of the molecules that make up the MHC.  These variants are learnt by the T cells that you produce so...

Research: Genetic Risk Factors and the HLA

Link J et al. Importance of Human Leukocyte Antigen (HLA) Class I and II Alleles on the Risk of Multiple Sclerosis. PLoS One. 2012;7(5):e36779. Epub 2012 May 7   Multiple sclerosis (MS) is a complex disease of the central nervous system of unknown etiology. The human leucocyte antigen (HLA) locus on chromosome 6 confers a considerable part of the susceptibility to MS, and the most...

Genetic variant predicts Tysabri failure

Rossi S et al. A genetic variant of the anti-apoptotic protein Akt predicts natalizumab-induced lymphocytosis and post-natalizumab multiple sclerosis reactivation.Mult Scler. 2012 May. [Epub ahead of print] Background: Multiple sclerosis (MS) patients discontinuing natalizumab treatment are at risk of disease reactivation. No clinical or surrogate parameters exist to identify patients at risk of...

Research: Another Susceptibility Locus

Matesanz F et al. Genome-wide association study of multiple sclerosis confirms a novel locus at 5p13.1.PLoS One. 2012;7(5):e36140. Epub 2012 May 3. Multiple Sclerosis (MS) is the most common progressive and disabling neurological condition affecting young adults in the world today. From a genetic point of view, MS is a complex disorder resulting from the combination of genetic and non-genetic...

Education: Classes of Evidence

When presenting abstracts were keep seeing class 1 and class 2 and class 3 evidence. But what does this mean? It is a classification that gives an indication of the quality, likeihood of a real effect, evidence. The scale rating differes from place to place. Evidence-based medicine (EBM) or evidence-based practice (EBP) aims to apply the best available evidence gained from the scientific method...

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