ArchiveJune 2012

Research Progression Onset

Tuntuncu M et al. Onset of progressive phase is an age-dependent clinical milestone in multiple sclerosis. Mult Scler. 2012 Jun 26. [Epub ahead of print] Background:It is unclear if all patients with relapsing-remitting multiple sclerosis (RRMS) ultimately develop progressive MS. Onset of progressive disease course seems to be age- rather than disease duration-dependent. Some forms...

CCSVI Monthly June

Below are this months offerings

Yes. beside the couple of offerings that Prof G has served up there is nothing to report this month. Maybe people just want to see what the clinical studies show. Maybe the scientific interest is waning.
Maybe it is time to kick this last saturday of the month slot into touch. Let’s see what July brings.

Research: skin reactions to glatiramer acetate

Mayorga et al. Immunological mechanisms underlying delayed-type hypersensitivity reactions to glatiramer acetate. Ann Allergy Asthma Immunol. 2012;109(1):47-51. BACKGROUND: Delayed-type hypersensitivity (skin allergy reaction) to glatiramer acetate is rare, and the underlying immunological mechanisms are not completely understood. OBJECTIVE: To study the immunologic response...

Research: anxiety, depression and fatigue are common in PwMS and tend to cluster together.

Epub: Wood B et al. Prevalence and concurrence of anxiety, depression and fatigue over time in multiple sclerosis. Mult Scler. 2012 Jun 22. Background: Anxiety, depression and fatigue are commonly reported by persons with multiple sclerosis (PwMS). Objectives: We estimated the prevalence of each factor in a representative sample of PwMS, and in subgroups defined by age, sex and disease duration...

Trial (TEMSO) of Teriflunomide

Miller AE, O’Connor P, Wolinsky JS, Confavreux C, Kappos L, Olsson TP, Truffinet P, Wang L, D’Castro L, Comi G, Freedman MS; for the Teriflunomide Multiple Sclerosis Trial Group.Pre-specified subgroup analyses of a placebo-controlled phase III trial (TEMSO) of oral teriflunomide in relapsing multiple sclerosis. Mult Scler. 2012 Jun 21. [Epub ahead of print] Background:The...

June: Unrelated Blogger Comments

Unrelated BLOGGER Comments Sometimes you what to say something that is unrelated to the threads. This is a spot for You.  You probably will not see you comment appear, please give it time it will appear eventually. If you have 2 to 3 minutes to spare he would appreciate it if you could complete the following survey: Internet Usage Survey Anonymous said… Not a comment but an important...

Research:Mitochondria and MS progression

Campbell et al. Clonally expanded mitochondrial DNA deletions within the choroid plexus in multiple sclerosis. Acta Neuropathol. 2012 Jun 12. Mitochondrial DNA deletions (mtDNA) have been implicated in the pathogenesis of Alzheimer’s disease (AD), MS and Parkinson’s disease (PD), as well as ageing. Clonal expansion = replication of mtDNA is the process by which a mutant...

Research: Melatonin and Progression

Natarajan et al. Melatonin pathway genes are associated with progressive subtypes and disability status in multiple sclerosis among Finnish patients. J Neuroimmunol. 2012 Jun.(epub) In this study we investigated the relationship between melatonin pathway and MS in a high-risk Finnish population by studying the single nucleotide polymorphisms (SNPs) in the genes coding for critical enzymes...

Research: Another Mechanism of Action of Gilenya

Epub: van Doorn et al. Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier. J Neuroinflammation. 2012;9:133. BACKGROUND: The sphingosine 1-phosphate (S1P) receptor modulator FTY720P (Gilenya(R)) potently reduces relapse rate and lesion activity in the neuroinflammatory disorder multiple sclerosis. Although most of its efficacy has been...

CCSVI. Whats in an Image?

 Before (left) and after (right) venoplasty. The ballon partially (centre right) and fully  (centre left) inflated. You have been questioning images from papers, so here is one. Is this stenois (thinning) of a vein? Is this successful venoplasty of  the vein. It looks like the thinning is reduced (but the thinning above the angioplasty is enhanced is it not?). Has it really stopped...

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