Epub: Pichler et al. Differences and similarities in the evolution of morphologic brain abnormalities between paediatric and adult-onset multiple sclerosis. Mult Scler. 2012 Jun 19. Background: Paediatric-onset multiple sclerosis (pMS) is MS occurring before the age of 18 years and may present and develop differently from adult-onset MS (aMS). Whether there are also differences regarding the...
Research Progression Onset
Tuntuncu M et al. Onset of progressive phase is an age-dependent clinical milestone in multiple sclerosis. Mult Scler. 2012 Jun 26. [Epub ahead of print] Background:It is unclear if all patients with relapsing-remitting multiple sclerosis (RRMS) ultimately develop progressive MS. Onset of progressive disease course seems to be age- rather than disease duration-dependent. Some forms...
An holistic approach to MS
“I have put this map together to illustrate an holistic approach to MS; i.e. what we need to think about it when considering the services we provide MSers. Have I left anything out? Thanks”
CCSVI Monthly June
Below are this months offerings
Yes. beside the couple of offerings that Prof G has served up there is nothing to report this month. Maybe people just want to see what the clinical studies show. Maybe the scientific interest is waning.
Maybe it is time to kick this last saturday of the month slot into touch. Let’s see what July brings.
New blog initiative: grand challenges in MS
After my talk last week, to the MSers at the East London branch of the MS Society, I have been contemplating “life the universe and everything”; that is “life the universe and everything to do with MS”. It is clear that despite researchers engaging with MSers at several levels there is still a disconnect between MSers and MS Researchers in what their aims, objectives...
Survey results: life expectancy
“The results are interesting; I need to contemplate them.” “It is clear that life expectancy is an important issue and that neurologists should choose the correct moment to discuss this information with MSers. It could be viewed as bad news are simply stating the obvious. The important message is that most of the data on reduced life expectancy in MS comes from the pre-DMT era...
Research: MS and stroke
Epub: Zöller et al. Risk of subsequent ischemic and haemorrhagic stroke in patients hospitalized for immune-mediated diseases: a nationwide follow-up study from Sweden. BMC Neurol. 2012;12(1):41. Background: Certain immune immune-mediated diseases (IMD) have been associated with increased risk for cardiovascular disorders. Aim: The aim of this study was to examine whether there is...
Research: skin reactions to glatiramer acetate
Mayorga et al. Immunological mechanisms underlying delayed-type hypersensitivity reactions to glatiramer acetate. Ann Allergy Asthma Immunol. 2012;109(1):47-51. BACKGROUND: Delayed-type hypersensitivity (skin allergy reaction) to glatiramer acetate is rare, and the underlying immunological mechanisms are not completely understood. OBJECTIVE: To study the immunologic response...
Research: lower risk of cancer in MS
Epub: Kingwell E et al. Cancer risk in multiple sclerosis: findings from British Columbia, Canada.Brain. 2012 Jun 21. Background: Findings regarding cancer risk in MSers have been inconsistent and few studies have explored the possibility of diagnostic neglect. The influence of a relapsing-onset versus primary progressive course on cancer risk is unknown. Objective: This study examined...
Research: can eye movements determine fatigue
Epub: Finke et al. Dynamics of saccade parameters in multiple sclerosis patients with fatigue. J Neurol. 2012 Jun. Background: Fatigue is one of the most frequent and disabling symptoms in MS. The mechanisms underlying fatigue remain poorly understood and objective measures to quantify fatigue are unavailable to date. Objective: To investigate whether analysis of ocular motor movements...