ArchiveJuly 2012

Stress management

Epub: van der Hiele et al. Daily hassles reported by Dutch multiple sclerosis patients. J Neurol Sci. 2012 Jul 14. Background: There is growing evidence for the association between stress and relapse risk in MS. The current study focuses on daily hassles, which by their chronic and accumulating nature can cause considerable psychosocial stress.  Aim: The main aim was to investigate the...

Research Pain in MS

Truini A, Galeotti F, La Cesa S, Di Rezze S, Biasiotta A, Di Stefano G, Tinelli E, Millefiorini E, Gatti A, Cruccu G.Mechanisms of pain in multiple sclerosis: A combined clinical and neurophysiological study. Pain. 2012 Jul. [Epub ahead of print] In this clinical and neurophysiological study, we examined the clinical characteristics and underlying mechanisms of neuropathic pain related to...

Unrelated Blogger comments 2

Unrelated Blogger Comments July-2 Unrelated BLOGGER Comments Sometimes you want to say something that is unrelated to the threads. This is a spot for you . “If you are a MSer at the Royal London Hospital please sign-up for our cognition study!” Anonymous said… I see you are recruiting for ppms. I turned 50 in June would I still be able to apply? Saturday, July 21, 2012...

Research: Interleukin 1 activity depends on lesion activityifferents

Epub: Murta et al. CNS response to a second pro-inflammatory event depends on whether the primary demyelinating lesion is active or resolved.Brain Behav Immun. 2012 Jul.  Interleukin-1 β (IL-1β) is considered to be one of the most important mediators in the pathogenesis of inflammatory diseases, particularly in neurodegenerative diseases such as multiple sclerosis (MS). MS is a chronic...

Interferon response genes and the therapeutic response to interferons

“The following study may be hard to understand if you don’t have a biology background. What these investigators are doing is simply studying variants in a gene that are affected by intereferon beta. Interferon beta is injected into your body and binds to a receptor on white blood cells causing it to change the way it functions. To do this interferon beta affects the way certain genes...

Olympics in London

                                    The River Thames in London in the Olympic stadium If you saw the Olympic opening ceremony on Friday (I know that elements of it were cut from the USA presentation…why?). Then being in East London things are going to be hectic for the next few weeks. Danny...

Survey results: cognition

“Unfortunately, our blogger polls can only give us headline results. We would need to study this in more detail to get an idea of the particular cognitive problems MSers who read this blog are having. I would be interested to find out!” “These results have important implications and are telling us that heathcare professionals are either not aware of the problem or they are...

Research: Early pathological changes in MS

Prineas JW, Parratt JD. Oligodendrocytes and the early multiple sclerosis lesion. Ann Neurol. 2012; 72:18-31 There is little agreement among neuropathologists regarding the timing and nature of oligodendrocyte loss in multiple sclerosis (MS). This report describes changes that accompany acute oligodendrocyte loss in new lesions. Included is a description of the immunopathology of new lesions in...

Primidone for MS tremor

Epub: Naderi et al. The Efficacy of Primidone in Reducing Severe Cerebellar Tremors in Patients With Multiple Sclerosis. Clin Neuropharmacol. 2012 Jul 19. OBJECTIVES: Cerebellar tremor is a very disabling sign of MS, and various kinds of treatments have been proposed with different results. Primidone is one of the medications, mostly advised for essential tremor. The aim of our study was to...

Research: a case for combined neuroprotection and immunomodulation

Braley et al. Differences in Diffusion Tensor Imaging-Derived Metrics in the Corpus Callosum of Patients WithMultiple Sclerosis Without and With Gadolinium-Enhancing Cerebral Lesions. J Comput Assist Tomogr. 2012;36:410-415.  OBJECTIVE: To analyze differences in corpus callosum diffusion tensor imaging metrics among MSers with RRMS and SPMS with enhancing and nonenhancing cerebral lesions...

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