ArchiveJuly 2012

Research Pain in MS

Truini A, Galeotti F, La Cesa S, Di Rezze S, Biasiotta A, Di Stefano G, Tinelli E, Millefiorini E, Gatti A, Cruccu G.Mechanisms of pain in multiple sclerosis: A combined clinical and neurophysiological study. Pain. 2012 Jul. [Epub ahead of print] In this clinical and neurophysiological study, we examined the clinical characteristics and underlying mechanisms of neuropathic pain related to...

Unrelated Blogger comments 2

Unrelated Blogger Comments July-2 Unrelated BLOGGER Comments Sometimes you want to say something that is unrelated to the threads. This is a spot for you . “If you are a MSer at the Royal London Hospital please sign-up for our cognition study!” Anonymous said… I see you are recruiting for ppms. I turned 50 in June would I still be able to apply? Saturday, July 21, 2012...

Research: Interleukin 1 activity depends on lesion activityifferents

Epub: Murta et al. CNS response to a second pro-inflammatory event depends on whether the primary demyelinating lesion is active or resolved.Brain Behav Immun. 2012 Jul.  Interleukin-1 β (IL-1β) is considered to be one of the most important mediators in the pathogenesis of inflammatory diseases, particularly in neurodegenerative diseases such as multiple sclerosis (MS). MS is a chronic...

Olympics in London

                                    The River Thames in London in the Olympic stadium If you saw the Olympic opening ceremony on Friday (I know that elements of it were cut from the USA presentation…why?). Then being in East London things are going to be hectic for the next few weeks. Danny...

Research: Early pathological changes in MS

Prineas JW, Parratt JD. Oligodendrocytes and the early multiple sclerosis lesion. Ann Neurol. 2012; 72:18-31 There is little agreement among neuropathologists regarding the timing and nature of oligodendrocyte loss in multiple sclerosis (MS). This report describes changes that accompany acute oligodendrocyte loss in new lesions. Included is a description of the immunopathology of new lesions in...

Research: surgery for facial pain

Mohammadi et al. Surgical outcomes of trigeminal neuralgia in patients with multiple sclerosis. Neurosurgery. 2012;71(2):E563-4. INTRODUCTION: Trigeminal neuralgia (TN) is relatively frequent in Multiple Sclerosis (MS) patients and procedural treatments are less effective than when used for classical TN. Outcomes from direct comparisons between different procedures for MS-related TN is lacking...

Research: predicting MS

Epub: Villar et al. High Levels Of Cerebrospinal Fluid Free Kappa Chains Predict Conversion To Multiple Sclerosis.Clin Chim Acta. 2012 Jul BACKGROUND: A clinically isolated syndrome (CIS) may be the initial presentation of multiple sclerosis (MS). However, some CIS never develop MS. The identification of patients at risk of MS conversion is crucial as early treatment may improve their outcome...

Research: Another action for Gilenya

Epub: van Doorn et al. Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes. Acta Neuropathol. 2012 Jul. Alterations in sphingolipid metabolism are described to contribute to various neurological disorders. We here determined the expression of enzymes involved in the sphingomyelin cycle and their products in postmortem...

MS Register

Epub: Ford et al.The feasibility of collecting information from people with Multiple Sclerosis for the UK MS Register via a web portal: characterising a cohort of people with MS. BMC Med Inform Decis Mak. 2012;12(1):73. BACKGROUND: A UK Register of people with Multiple Sclerosis has been developed to address the need for an increased knowledge-base about MS. The Register is being populated via: a...

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