Research: Cannabinoind and progression


Cannabidiol (CBD) is the most abundant cannabinoid in Cannabis sativa
that has no psychoactive properties. CBD has been approved to treat
inflammation, pain and spasticity associated with multiple sclerosis
(MS), of which demyelination and oligodendrocyte loss are hallmarks.
Thus, we investigated the protective effects of CBD against the damage
to oligodendrocyte progenitor cells (OPCs) mediated by the immune
system. Doses of 1 μM CBD protect OPCs from oxidative stress by
decreasing the production of reactive oxygen species. CBD also protects
OPCs from apoptosis induced by LPS/IFNγ through the decrease of caspase 3
induction via mechanisms that do not involve CB1, CB2, TRPV1 or PPARγ
receptors. Tunicamycin-induced OPC death was attenuated by CBD,
suggesting a role of endoplasmic reticulum (ER) stress in the mode of
action of CBD. This protection against ER stress-induced apoptosis was
associated with reduced phosphorylation of eiF2α, one of the initiators
of the ER stress pathway. Indeed, CBD diminished the phosphorylation of
PKR and eiF2α induced by LPS/IFNγ. The pro-survival effects of CBD in
OPCs were accompanied by decreases in the expression of ER apoptotic
effectors (CHOP, Bax and caspase 12), and increased expression of the
anti-apoptotic Bcl-2. These findings suggest that attenuation of the ER
stress pathway is involved in the ‘oligoprotective’ effects of CBD
during inflammation.

CBD has been approved to treat inflammation, pain and spasticity associated with MS…No it has not!!!!!. 

Sativex which contains THC and CBD has been approved for treatment of pain and spasticity and not inflammation. There is no published evidence that CBD alone has these benefits in MS. Indeed the biology suggests that it is the THC (Tetrahydrocannabinol) in the sativex mixture that is the major active ingredient in symptom control. However does CBD and THC have the potential to do other things? Yes they do. Unforutntately the CUPID trial has not shown benefit for treating prrogressive MS but the biology and experimental data both suggested that it had the potential to do so. 

This study suggests that CBD is not an inert partner in the Sativex mixture and may provide some capacity to affect limiting the processes associated with progression. However this was work in a text tube and there is no evidence that this occurs in MS.

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  • There's so many doctors that say they're confident that a solid treatment for progressive MS is a few years away. Even MouseDoctor Part II said "great strides are being made."

    How long is a piece of string? How come you never report on these great strides? All I hear about nowadays on this blog is terminal phases of MS and funding rejections.

    Can we have some promising news please?

  • We don't make the news we just report it (OK sometimes we do sometimes make the news).

    If there is something great to report, we report it, it there is no news, we are not going to make things up just to try and make the situtation look more rosey.

    As to rejections, this is part of the research and one needs to understand this, because this is one of the reasons why things do not move at the pace that you and I want.

    Likewise on the blog we have to show you the reallity of what has to occur for drugs to be developed and so you can why it takes so long and why it is an expensive process

    As too great strides… what is big to me may not be big to you and until we get positive news that progression is being slowed I suspect that one will not be satisfied whatever we say.

    MD2 can see that we have ways to potentially slow progression, because he has discovered a bunch and worked with a bunch more but it will take time to make that translate into treatments for MSers.

    As for terminal phases etc. it is also important that you are aware about what MS is and where it can leadso that you are informed.

    This is because some of the new drugs come with real potential to make an impact on MSers, but some come with significant life threatening risks. Knowledge (good and bad) is the key to help make informed choices.

    How long is a piece of string?

    Twice the distance from the middle to the end:-)

  • "If true they are ahead of the game"

    I am afraid not..there are High THC low CBD variants of marijuana..this is "Mexican" variants and there are high CBD variants.

    Sativex used for MS is not made from one plant variety but two. One high in THC and the other high in CBD low in THC and they are mixed one to one. So the high CBd variant has been around for years


  • "There's so many doctors that say they're confident that a solid treatment for progressive MS is a few years away. Even MouseDoctor Part II said "great strides are being made.""

    Even the 100 metres takes more than one great stride from Usain Bolt. Believe me, things are definitely moving forward, though obviously we all wish it could be quicker.

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