Research: Fenofibrate a novel Th17 inhibitor

R

Uncontrolled activity of T cells mediates autoimmune and inflammatory diseases such as multiple sclerosis,
inflammatory bowel diseases, rheumatoid arthritis, type 1 diabetes, and
atherosclerosis. Recent findings suggest that enhanced activity of
interleukin-17 (IL-17) producing T helper 17 cells (Th17 cells) plays an
important role in autoimmune diseases and inflammatory diseases.



In the
present study, we hypothesized that fenofibrate (a synthetic ligand of
peroxisome proliferator-activated receptor α (PPARα))  inhibited the
differentiation of Th17 cells. Our results showed that fenofibrate
inhibited transforming growth factor-β (TGF-β) and IL-6-induced
differentiation of Th17 cells in vitro. However, other PPARα ligands
such as WY14643, GW7647 and bezafibrate did not show any effect on Th17
differentiation, indicating that this effect of fenofibrate might be
PPARα independent. Furthermore, our data showed that fenofibrate reduced
IL-21 production and STAT3 activation, a critical signal in the Th17
differentiation. Thus, by ameliorating the differentiation of Th17
cells, fenofibrate might be beneficial for autoimmunity and inflammatory
diseases.




Yet another publication on Th17 cells. This study suggests that .fenofibrate could be of use in MS, but it is just hypothetical and much work would needs to be done to show it has any real value in MS. 

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MouseDoctor

4 comments

  • Anon 8.29
    Prof G has posted this you tube post about Big Pharma Bribery Post.

    Wish I was on the $1800 an hour?. However if pharma is using your skills or tapping your knowledge they should need to pay.

    Exposed..medicine…weapons?

    I think you should still trust your drug-pimping doctor

    Pimp G HaHa:-) I guess we are his Hos

  • Please, just regard posts by Murray as based on sincere civil contributions, civil, and based on reason and referenced public evidence — my area of knowledge since 1999 is aspartame methanol formaldehyde — highly relevant is that formaldehyde modified brain cell proteins are potent triggers for immune system overreactions — this is so basic that much MS research has been floundering for decades…

  • Sorry posts by Murray are trolling spam. We want comments on current research not armchair science.

    Learn something new…like politeness and stop posting this waffle. We have asked numerous times

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