Research: Race and response to DMT


Klineova S, Nicholas J, Walker A Response to disease modifying therapies in African Americans with multiple sclerosis. Ethn Dis. 2012 Spring;22(2):221-5.

BACKGROUND: The African American (AA) population has a lower risk for developing multiple sclerosis (MS) than Caucasian (CA) population; however, the disease tends to be more severe with early disability in AA. The reason underlying the discrepancy in disease severity is not yet understood, and it could be caused by different response to disease modifying therapies (DMTs).

OBJECTIVE:  To evaluate whether there are significant differences in profile of response to disease modifying therapies related to ethnicity, while controlling for disease characteristics.

DESIGN: We performed a retrospective chart analysis of MS patients undergoing treatment with DMTs. Rating of disease progression was based on expanded disability status score (EDSS) difference at the time of first and last visit.

RESULTS: Sex and age at the time of diagnosis did not differ significantly between AA and CA. There was statistically significant difference in disease duration, which was longer among CA patients (P < .001). Median of EDSS difference was higher in AA population than in CA population (P < .001). Increased EDSS difference suggests poorer response to DMTs among AA patients in our study.

CONCLUSIONS: AA patients showed poorer response to DMTs when compared with CA patients. This suggests a trend, however, further prospective studies on the response of AA patients to DMTs are warranted.

Conclusions say it all, but is perhaps an example of how different genetic variants in this group of MSers may be a factor in how people respond to drugs

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  • Enough with the methanol cack!
    Also if you recall the smell of ether (as anaaethetic) you must be seriously old!!!

  • yeah, is 70 on July 3 "seriously old?" ? Maybe I don't know what I smelled — I was 9 in April, 1953 in Beaumont, SE Texas, E of Houston, after I was knocked out on the street with a bad head concussion, a few days later for a spinal tap air contrast X-ray — maybe "ether" was a generic term — the needle site has had a wicked twitch a few times a year ever since — the smell seemed familiar at age 9 as age 5 …

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