Research: Interleukin -7 a risk factor is reduced in MS

R
Polymorphisms (single-nucleotide polymorphism (SNP)) in the
interleukin-7 receptor-α (IL-7Rα)/IL-7 pathway are associated with an
increased risk to develop multiple sclerosis
(MS). The rs6897932 SNP in the IL-7Rα leads to increased soluble IL-7Rα
production. Given the functional interaction between sIL-7Rα,
membrane-bound IL-7Rα and IL-7, we assessed IL-7, mIL-7Rα and sIL-7Rα
levels in MS patients and healthy controls (HCs). One-hundred and twenty
eight MS patients had significantly lower sIL-7Rα levels compared with
73 HCs. The levels of sIL-7Rα increased dose-dependent upon rs6897932
[C] risk allele carriership in both HCs and MS. Next, we hypothesized
that lower sIL-7Rα could result in a higher mIL-7Rα to soluble IL-7Rα
ratio. Indeed, 52 MS patients had significantly increased mIL-7Rα to
sIL-7Rα ratio for both CD4 and CD8 T cells compared with 44 HCs. Given
the supposed role of IL-7 in autoimmunity, we determined whether sIL-7Rα
influences IL-7 levels. IL-7 levels were significantly decreased in 40
MS patients compared with 40 HCs. In conclusion, MS patients had lower
free IL-7 and a higher membrane to soluble IL-7Rα ratio. The soluble
IL-7Rα levels correlate with the rs6897932 [C] risk allele carriership.
The skew at the IL-7 and IL-7Rα level may influence responsiveness of
IL-7Rα(+) cells

Genes relating to the interleukin 7 receptor, which binds interleukin 7 (IL-7), which is a white blood cell growth factor are linked to the susceptibility of MS. When IL-7 receptor (soluble IL-7R) is shed from cells if floats around the blood mopping up IL-7. The genetic variant as receptorsocated with MS leads to an increase in the production of the shedv version of IL-7 receptor and indeed people with MS had lower IL-7 in their blood. HOw this actually influences MS is unknown but it is likely going to be something to do with the development of the immune response.

About the author

MouseDoctor

Add comment

By MouseDoctor

Translate

Categories

Recent Posts

Recent Comments

Archives