ArchiveSeptember 2012

Education: Conflicts of Interest:The case of Missing patents

Someone stated that there was this Doc who always declared conflicts of interests and that we were a bit wrong to suggest that they did not, so maybe time to refresh on Conflicts of Interest What is a competing interest well this is one papers stance (PLOS) It is increasingly recognized that everyone — authors, authors’ employers (e.g., an academic institution, government department...

Research: cognitive decline in MSers especially in men

Epub: Schoonheim et al. Subcortical atrophy and cognition: Sex effects in multiple sclerosis. Neurology. 2012 Sep 26. OBJECTIVES: Gray matter (GM) atrophy is common in multiple sclerosis (MS), as is cognitive dysfunction. Understanding the exact relationship between atrophy and cognition requires further investigation. The aim of this study was to investigate the relationship between...

Research: transcribing people with MS

Ottoboni et al. An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity. Sci Transl Med. 2012;4(153):153ra131. The multiple sclerosis (MS) patient population is highly heterogeneous in terms of disease course and treatment response. We used a transcriptional profile generated from peripheral blood mononuclear cells to define the structure of an MS...

Research: More Big science of the Human Brain

Hawrylycz et al..An anatomically comprehensive atlas of the adult human brain transcriptome. Nature. 2012;489(7416):391-9. doi: 10.1038/nature11405. Neuroanatomically precise, genome-wide maps of transcript distributions are critical resources to complement genomic sequence data and to correlate functional and genetic brain architecture. Here we describe the generation and analysis of a...

Unrelated Blogger Comments September 2

Sometimes you what to say something that is unrelated to the threads. This is a spot for You. Previous comments can be got at on the posts on the right of the main page.  Gavin Giovannoni said… Re: “Ground fish dumplings at Le Poelon d’Or is a nice place to start. 29 rue des Remparts d’Ainay (+33 (0)4 78 42 43 42).” Thanks for your recommendations; I will...

Neural Stem Cells Will be No Use as Immunomodulators

Fainstein N, Einstein O, Cohen ME, Brill L, Lavon I, Ben-Hur T. Time limited immunomodulatory functions of transplanted neural precursor cells. Glia. 2012 Sep 21. doi: 10.1002/glia.22420. [Epub ahead of print]. Foetal neural stem/precursor cells (NPCs) possess powerful immunomodulatory properties which enable them to protect the brain from immune-mediated injury. A major issue in developing...

Survey results: disease-activity free status

“Are yiou surprised with these results? I am not. They do indicate, however, that we have a lot of work to do to get this concept accepted by the wider clinical community and more importantly into clinical practice. Let’s hope the community is ready for the concept. It is very important for MSers; at least those with RRMS.”

Research: predicting efficacy of interferon-beta

Epub: Sormani et al. Scoring treatment response in patients with relapsing multiple sclerosis. Mult Scler. 2012 Sep 25. BACKGROUND: Clinical and MRI) measures in combination, to assess patient responses to interferon in multiple sclerosis. OBJECTIVE: To optimize and validate a scoring system able to discriminate responses to interferon treatment in RRMSers. METHODS: The analysis included two...

Research: Making Myelination

Lee et al. A culture system to study oligodendrocyte myelination processes using engineered nanofibers. Nat Methods. 2012;9(9):917-22. Current methods for studying central nervous system myelination necessitate permissive axonal substrates conducive to myelin wrapping by oligodendrocytes. We have developed a neuron-free culture system in which electron-spun nanofibers of varying sizes substitute...

Research:Falling and activity

Epub: Sosnoff et al. Falls and physical activity in persons with multiple sclerosis. Mult Scler Int. 2012;2012:315620. Objectives: To examine the association between fall history and physical activity using an objective measure of physical activity (i.e., accelerometry) in MSers. Design: A community-based sample of 75 ambulatory MSers volunteered for the investigation. Participants self...

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