ArchiveOctober 2012

Lethal MS post-natalizumab

Epub: Rigau et al. LETHAL MULTIPLE SCLEROSIS RELAPSE AFTER NATALIZUMAB WITHDRAWAL. Neurology. 2012 Oct 24. Natalizumab dramatically reduces relapses in MSers with active MS, but it may induce progressive multifocal leukoencephalopathy (PML).(1) A rebound of MS or an immune reconstitution inflammatory syndrome (IRIS) were described after natalizumab withdrawal, even in the absence...

Rivastigmine fails to show effects on cognition

Epub: Mäurer et al. Randomised multicentre trial on safety and efficacy of rivastigmine in cognitively impaired multiple sclerosis patients. Mult Scler. 2012 Oct. BACKGROUND: Cognitive decline has been recognised as a frequent symptom in multiple sclerosis (MS). Cholinesterase inhibitors (ChEIs) are employed for the treatment of Alzheimer’s disease, but there is some evidence that...

Blog in the Media

The Blog been recognised for excellence due to the contribution its top quality editorial offers the Multiple Sclerosis world by KwikMed. This year, their specialist panel of judges have reviewed hundreds of different sites from across the internet before hand-picking the very best for each category. The Blog is among the elite selection of awardees that our judges felt made a real contribution...

What do we know about the genetics of MS?

Epub: Watson CT, Disanto G, Breden F, Giovannoni G, Ramagopalan SV. Estimating the proportion of variation in susceptibility to multiple sclerosis captured by common SNPs. Sci Rep. 2012;2:770. Epub 2012 Oct 25. Multiple sclerosis (MS) is a complex disease with underlying genetic and environmental factors. Although the contribution of alleles within the major histocompatibility complex (MHC)...

Natalizumab PML Update – September 2012

“Apologies about not getting these latest figures to you. I have also included the presentation from Biogen-Idec for your information.” Natalizumab Safety Update September 2012 from gavingiovannoni “As at the 5th September, 2012, there have been 285 reported cases of MSers with PML as a complication of natalizumab treatment. This is with a denominator of over 104,000 treated...

Unrelated Blogger Comments 2 – October

Sometimes you what to say something that is unrelated to the threads. This is a spot for You. Previous comments can be got at on the posts on the right of the main page.

Prof G has changed the comments posts so they do not pop-up but allows replies. Let us know what you prefer
P.S. Check out MouseDoc & The Not so Great North Run

Research: Repair of grey matter lesions

Chang A, Staugaitis SM, Dutta R, Batt CE, Easley KE, Chomyk AM, Yong VW, Fox RJ, Kidd GJ, Trapp BD.  Cortical remyelination: A new target for repair therapies in multiple sclerosis. Ann Neurol. 2012  doi: 10.1002/ana.23693. [Epub ahead of print] OBJECTIVE: Generation and differentiation of new oligodendrocytes in demyelinated white matter is the best described repair...

Disease reactivation after cessation of natalizumab and switching to fingolimod

Rinaldi et al. Switching therapy from natalizumab to fingolimod in relapsing-remitting multiple sclerosis: clinical and magnetic resonance imaging findings. Mult Scler. 2012;18:1640-3. Background: Clinical and/or neuroimaging evidence of disease reactivation has been described in MSers  after a break from natalizumab.  Objective: To evaluate fingolimod as therapeutic option following...

Not So Great North Run

If you are like me, I can’t run and  so I’m doing the Not So Great North Run on 9th December 2012. This is a half marathon with a twist My travel is not going to be in the North of England but North London in a Gym. There I aim to travel the equivalent of 13.1 miles on a Low-Impact Cross Trainer. Why don’t you join me and pop down to your local gym...

Restless leg Syndrome

Epub: Schürks & Bussfeld. Multiple sclerosis and restless legs syndrome: a systematic review and meta-analysis. Eur J Neurol. 2012 Oct 18. doi: 10.1111/j.1468-1331.2012.03873.x.  BACKGROUND: Restless legs syndrome (RLS) has been reported to occur more frequently in patients with multiple sclerosis (MS) than in people without MS.METHODS: Systematic review and meta-analysis of studies...

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