ArchiveOctober 2012

Post traumatic Stress

Epub: Ostacoli et al. Prevalence and Significant Determinants of Post-traumatic Stress Disorder in a Large Sample of Patients with Multiple Sclerosis. J Clin Psychol Med Settings. 2012 Oct. Background: Chronic and life-threatening neurodegenerative diseases may be associated with post-traumatic stress disorder (PTSD).  Aims: Therefore, the current study was an investigation of the prevalence...

Research: Genetics of MS

Epub: O’Gorman C, Lin R, Stankovich J, Broadley SA. Modelling Genetic Susceptibility to Multiple Sclerosis with Family Data. Neuroepidemiology. 2012; 40:1-12. A genetic contribution to susceptibility is well established in multiple sclerosis (MS) and 57 associated genetic loci have been identified. We have undertaken a meta-analysis of familial risk studies with the aims of providing...

Research: information about having a baby with MS

Epub: Kosmala-Anderson & Wallace. A qualitative study of the childbearing experience of women living with multiple sclerosis. Disabil Rehabil. 2012 Oct 17. Background: Although at any time in the UK, there are about 20,000 women with MS who may be considering having children, healthcare systems often fail to provide them with information and support they need to make informed decisions about...

Research: hepatitis B vaccination is not a risk factor for MSers

Epub: Martínez-Sernández & Figueiras. Central nervous system demyelinating diseases and recombinant hepatitis B vaccination: a critical systematic review of scientific production. J Neurol. 2012 Oct. Background: The aetiology of MS has not yet been fully described. A potential link between the recombinant hepatitis B vaccine and an increased risk of onset or exacerbation of MS emerged in...

ECTRIMS 2012: alemtuzumab presentation

“Several people have now requested my slides on Alemtuzumab that I presented as part of the Genzyme satellite symposium at ECTRIMS. I have now loaded them onto slideshare for you to view and download.”  “The aim of this presentation was to present the phase 3 trial data on Alemtuzumab in early RRMS as a therapeutic strategy that probably works by depleting circulating...

CCSVI survey results. BLOG readers are sceptical

The survey results on CCSVI have been interesting. When asking Prof G to the post survey, I would have predicted that if all trials were positive the majority of people would believe them and we would then move forward and push to get the treatment made available. If negative the majority should believe that and move on. However I expected a few people to not believe anything, maybe people who...

CCSVI Monthly October

As the nonsense arrives, whenever there is a contentious post on CCSVI, to keep some balance for those interested, we will go back to the last Saturday of the month with no comments taken. Make your own mind up and keep it to yourself. Epub: Sati et al. FLAIR*: A Combined MR Contrast Technique for Visualizing White Matter Lesions and Parenchymal Veins. Radiology. 2012 Oct 16. Purpose: To evaluate...

Research: Men more likely to have More Nerve damage than Women

Epub: Costello et al. Sex-specific differences in retinal nerve fiber layer thinning after acute optic neuritis. Neurology. 2012 Oct 17. OBJECTIVE: The primary objective of this study was to explore the potential influence of gender on recovery from optic neuritis (ON) by determining whether differences in retinal nerve fiber layer (RNFL) thickness can be detected between men and women 6 months...

Protein-protein interactions

Epub: Ragnedda et al. Protein-protein interaction analysis highlights additional Loci of interest for multiple sclerosis. PLoS One. 2012;7(10):e46730. doi: 10.1371/journal.pone.0046730. Genetic factors play an important role in determining the risk of multiple sclerosis (MS). The strongest genetic association in MS is located within the major histocompatibility complex class II region (MHC), but...

Research: Statins and Immune function

Zhang X, Tao Y, Wang J, Garcia-Mata R, Markovic-Plese S. Simvastatin inhibits secretion of Th17-polarizing cytokines and antigen presentation by DCs in patients with relapsing remitting MS.Eur J Immunol. 2012 Oct 17. doi: 10.1002/eji.201242566. [Epub ahead of print] Statins, widely used cholesterol-lowering agents, have also been demonstrated to have anti-inflammatory effects. Here we...

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