ArchiveNovember 2012

Hit hard and early!

The slides from my talk in Marbella; you can download them from my slideshare site!  “The main messages in the talk are: 1. We must adopt treatment practices from oncology (NEDD) and rheumatology (TTT) to render MSers DAF (disease-activity free).  2. We need to formulate a definition of what a cure in MS will look like and work towards this aim. 3. We must not assume that anti...

Research: markers of severity?

Epub: Lindén et al. Multiple sclerosis risk genotypes correlate with an elevated cerebrospinal fluid level of the suggested prognostic marker CXCL13. Mult Scler. 2012 Nov. BACKGROUND: The mechanisms of multiple sclerosis (MS) pathogenesis are still largely unknown. The heterogeneity of disease manifestations make the prediction of prognosis and choice of appropriate treatment protocols...

Practising to be Santa

You like to comment on Prof Gs jollies, so next week and a bit involves flying back and forth to USA and back to UK for a day meeting and then back to USA and so on….Think how much fun this is. In contrast I get to travel see the world for a MS meeting in Reagents Park…isn’t London the centre of the Universe? In the words of Dizzy Rascal..you may remember from the...

Research Day Advent Calender Starting Soon

Following on from lasts years bit of December fun, it is again time for the House of Mouse Christmas Advent Calender.  Last year my outfits were themed around the festive season but this year, I will dress up to introduce you to members of Team G.  Earlier on in the year I was seen in my special MS orange lab coat. Who Will We Get…I bet Team G Can’t Wait to Find Out Tickets...

The BigPharma Alternative

#MSBlog: Is there an alternative to BigPharma? Help make it happen! Is there an alternative to Big Pharma for developing new drugs for MS?  With the current level of risk associated with drug development and the level of regulatory red-tape it seems unlikely. Even Big Pharma themselves are having second thoughts about the current paradigm and trying new things. Many companies have closed...

All Party Parlimentary Group for Multiple Sclerosis

Minster for Health; Jeremy Hunt (Constiuency-South West Surrey)  Did you know that there is the All-Party Parliamentary Group for Multiple Sclerosis who aim To promote the interests of people affected by MS.  Now we know who to lobby Chair               Lord DubsVice-Chairs     Stephen Lloyd, David...

Research: Blood Products triggers Microglia to cause Damage

Davalos D et al. Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation Nat. Commun. 3 : 1227 doi:10.1038/ncomms2230 (2012)  Blood-brain barrier disruption, microglial activation and neurodegeneration are hallmarks of multiple sclerosis. However, the initial triggers that activate innate immune responses and their role in...

Research: Measuring Fatigue

Epub: Yu et al. A wireless body measurement system to study fatigue in multiple sclerosis. Physiol Meas. 2012;33(12):2033-2048.  Fatigue is reported as the most common symptom by patients with multiple sclerosis (MS). The physiological and functional parameters related to fatigue in MS patients are currently not well established. A new wearable wireless body measurement system, named...

ECF Meeting Marbella: natural history and gut microbiota

#MSBlog: Hit hard and early! “I will be speaking at the European Charcot Foundation meeting in Marbella later this week (see programme below). I am talking in the session on “Time to change the treatment paradigm for people with MS?” I assume the question mark is asking whether or not the time for this is now or in the future.  My talk is on “Hit hard and...

Education: progressive MSers in the same boat.

There has been some questions about the course of MS and whether the cause of relapsing MS and progressive MS are dependent or independent. Prof G is not sure if the two are dependent on each other, based on animal studies I would say they are probably independent mechanisms, but inter-related.   If you look at the age of onset of MS (Left graph-This is perhaps a bit loose as I am sure MS my...

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