ArchiveNovember 2012

Research: markers of severity?

Epub: Lindén et al. Multiple sclerosis risk genotypes correlate with an elevated cerebrospinal fluid level of the suggested prognostic marker CXCL13. Mult Scler. 2012 Nov. BACKGROUND: The mechanisms of multiple sclerosis (MS) pathogenesis are still largely unknown. The heterogeneity of disease manifestations make the prediction of prognosis and choice of appropriate treatment protocols...

Practising to be Santa

You like to comment on Prof Gs jollies, so next week and a bit involves flying back and forth to USA and back to UK for a day meeting and then back to USA and so on….Think how much fun this is. In contrast I get to travel see the world for a MS meeting in Reagents Park…isn’t London the centre of the Universe? In the words of Dizzy Rascal..you may remember from the...

Research Day Advent Calender Starting Soon

Following on from lasts years bit of December fun, it is again time for the House of Mouse Christmas Advent Calender.  Last year my outfits were themed around the festive season but this year, I will dress up to introduce you to members of Team G.  Earlier on in the year I was seen in my special MS orange lab coat. Who Will We Get…I bet Team G Can’t Wait to Find Out Tickets...

All Party Parlimentary Group for Multiple Sclerosis

Minster for Health; Jeremy Hunt (Constiuency-South West Surrey)  Did you know that there is the All-Party Parliamentary Group for Multiple Sclerosis who aim To promote the interests of people affected by MS.  Now we know who to lobby Chair               Lord DubsVice-Chairs     Stephen Lloyd, David...

Research: Blood Products triggers Microglia to cause Damage

Davalos D et al. Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation Nat. Commun. 3 : 1227 doi:10.1038/ncomms2230 (2012)  Blood-brain barrier disruption, microglial activation and neurodegeneration are hallmarks of multiple sclerosis. However, the initial triggers that activate innate immune responses and their role in...

Research: Measuring Fatigue

Epub: Yu et al. A wireless body measurement system to study fatigue in multiple sclerosis. Physiol Meas. 2012;33(12):2033-2048.  Fatigue is reported as the most common symptom by patients with multiple sclerosis (MS). The physiological and functional parameters related to fatigue in MS patients are currently not well established. A new wearable wireless body measurement system, named...

Education: progressive MSers in the same boat.

There has been some questions about the course of MS and whether the cause of relapsing MS and progressive MS are dependent or independent. Prof G is not sure if the two are dependent on each other, based on animal studies I would say they are probably independent mechanisms, but inter-related.   If you look at the age of onset of MS (Left graph-This is perhaps a bit loose as I am sure MS my...

Research: cognitive impairment in young MSers

Epub: Julianet al. Cognitive Impairment Occurs in Children and Adolescents With Multiple Sclerosis: Results From a United States Network. J Child Neurol. 2012 Nov. In the largest sample studied to date, we measured cognitive functioning in children and adolescents with pediatric multiple sclerosis (n = 187) as well as those with clinically isolated syndrome (n = 44). Participants were...

Research: Course in Young MSers

Harding KE, Liang K, Cossburn MD, Ingram G, Hirst CL, Pickersgill TP, Te Water Naude J, Wardle M, Ben-Shlomo Y, Robertson NP. Long-term outcome of paediatric-onset multiple sclerosis: a population-based study. J Neurol Neurosurg Psychiatry. 2012 Nov 15. [Epub ahead of print] BACKGROUND: Age of onset of multiple sclerosis (MS) peaks in the 3rd and 4th decades and is rarely less than 18...

The Elephant in the Room.

“Elephant in the room” This is an English metaphorical idiom for an obvious truth that is either being ignored or going unaddressed. The idiomatic expression also applies to an obvious problem or risk no one wants to discuss. It is based on the idea that an elephant in a room would be impossible to overlook; thus, people in the room who pretend the elephant is not there have chosen to...

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