Research: Measuring Fatigue

Epub: Yu et al. A wireless body measurement system to study fatigue in multiple sclerosis. Physiol Meas. 2012;33(12):2033-2048. 

is reported as the most common symptom by patients with multiple
sclerosis (MS). The physiological and functional parameters related to
fatigue in MS patients are currently not well established. A new
wearable wireless body measurement system, named Fatigue Monitoring
System (FAMOS), was developed to study fatigue in MS. It can
continuously measure electrocardiogram, body-skin temperature,
electromyogram and motions of feet. The goal of this study is to test
the ability of distinguishing fatigued MS patients from healthy subjects
by the use of FAMOS. This paper presents the realization of the
measurement system including the design of both hardware and dedicated
signal processing algorithms. Twenty-six participants including 17 MS
patients with fatigue and 9 sex- and age-matched healthy controls were
included in the study for continuous 24 h monitoring. The preliminary
results show significant differences between fatigued MS patients and
healthy controls. In conclusion, the FAMOS enables continuous data
acquisition and estimation of multiple physiological and functional
parameters. It provides a new, flexible and objective approach to study
fatigue in MS, which can distinguish between fatigued MS patients and
healthy controls. T
he usability and reliability of the FAMOS should
however be further improved and validated through larger clinical

Get the system improved so that it is an available tool to measure fatigue, which is very high on the list of problems with MS, but very under investigated. However, with tools to monitor are a step towards being able to treat. Part of the slowness in progress in MS is the lack of responsive outcomes

About the author



  • Chronic fatigue cut short my business career in my 30s, taking with it my financial security and potential. Twenty-some years later, I cannot recall what it feels like to function without fatigue's fog. Sadly, the fatigue feels "normal."

  • I have been diagnosed with Multiple Sclerosis. The diagnosis was made here in Berlin 5 and a half years ago.I was 34 years old at the time and had 2 children. I now have three children. I often feel very tired -indeed fatigued. I tend to think this is due to the intensive demands of motherhood, night interruptions etc and don't think I differ from other mothers in my age-group at all. One thing I have noticed and I believe this is due to MS – I cannot jog more than 3km any more (I used to run half marathons and until about a year ago, enjoyed up to 7km runs.) I also do notice and have noticed for many years, cognitive impairment and real difficulty to concentrate myself on subjects, even those that really interest me.Short bursts of sport really help this temporarily.


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