ArchiveDecember 2012

Research: fingolimod after natalizumab keeps relapses at bay

  #MSBlog: How soon after stopping natalizumab (Tysabri) do you start fingolimod (Gilenya)?   Epub: Havla et al. Fingolimod reduces recurrence of disease activity after natalizumab withdrawal in multiple sclerosis. J Neurol. 2012. Background: After discontinuation of natalizumab (Nz), MS disease activity often recurs.   “The level of rebound activity can be very severe!”  ...

Research: Effect of Natalizumab on T cells

  Epub: Börnsen et al. Effect of Natalizumab on Circulating CD4(+) T-Cells in Multiple Sclerosis. PLoS One. 2012;7(11):e47578. doi: 10.1371/journal.pone.0047578. Epub 2012 Nov 30.In multiple sclerosis (MS), treatment with the monoclonal antibody natalizumab effectively reduces the formation of acute lesions in the central nervous system (CNS). Natalizumab binds the integrin very late antigen...

Research Day 31

  So this Concludes the House of Mouse Month. It is back to the boring white lab coat.   Tomorrow brings another Year,  with New Challenges and New Goals.    It may have been a monstrous 2012 to some people and Not Others..Prof G is easily pleased, but lets hope we do better in 2013.   Have a festive New Years Eve where every you are and    Don’t drink too much Pop! If you...

Unrelated Blogger Comments New Years Eve

Sometimes you want to say something that is unrelated to the threads. This is a spot for You. Previous comments can be got at on the posts on the right of the main page.

We may be a bit slow responding over the festive period. Please be patient we will get back to you ASAP!

Research: clearing up myelin debris

Epub: Fernandez-Castaneda et al. Identification of the LDL Receptor-Related Protein-1 Interactome in Central Nervous System myelin suggests a role in the clearance of necrotic cell debris. J Biol Chem. 2012 Dec  In the central nervous system (CNS), fast neuronal signals are facilitated by the oligodendrocyte-produced myelin sheath. Oligodendrocyte turnover or injury generates myelin...

Research Gender differences in MS

  Epub: Rojas et al. Sex-related differences in atrophy and lesion load in multiple sclerosis patients. Neurologia. 2012 Dec 13. doi:pii: S0213-4853(12)00277-0. 10.1016/j.nrl.2012.10.008.INTRODUCTION: Previous studies showed gender-associated clinical and MRI differences in multiple sclerosis (MS) evolution. However, only few studies were done with non conventional MRI techniques and no one...

Research: Genetic pathways of MS

Epub: Song et al. Genome-wide pathway analysis of a genome-wide association study on multiple sclerosis. Mol Biol Rep. 2012 Dec 14. Aims: The aims of this study were to identify candidate single nucleotide polymorphisms (SNPs) and mechanisms of multiple sclerosis (MS) and to generate SNP to gene to pathway hypotheses. Methods: A MS genome-wide association study (GWAS) dataset that included...

Research Day 30

The stars of the Preclinical Research Work of TeamG Mr & Mrs BiozziMouse Guido Biozzi was a Brazilian working in the Institute Curie in Paris, France.  In order to study the genetic regulation of the Immune response he made a cross between white Swiss mice.  At each generation took the mice that produced either high or low amounts of antibody and bred them together so that...

Unrelated Blogger Comments 30

Sometimes you want to say something that is unrelated to the threads. This is a spot for You. Previous comments can be got at on the posts on the right of the main page.

We may be a bit slow responding over the festive period. Please be patient we will respond as soon as possible!

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