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MouseDoctor

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  • That's what we all long for.

    What's yout best guess for how much longer it will be?

    Do you think 'mystery solved' and 'patient cured' will come together?

    • I am not sure how long it will take. If may be very quick, for example, The Charcot Project may provide the answer. If MS responds to specific anti-virals the mystery may be solved very quickly. But don't hold your breath. The anti-viral strategy is a long-shot, but one worth taking as the drugs that we are targeting are reasonable safe.

  • Professor, before testing the viral theory with The Charcot Project you must have at least formalised a draft viral theory of lesion formation. Can you explain us your concept of the viral way of BBB disruption and lesion formation? We have already heard all the statistical arguments in favor of the EBV hypothesis, but have never seen a plausible mechanism to account for the available data regarding formation, evolution and contents of MS lesions.

    • Come to research day and you can get one mechanisms of the EBV hypothesis and how this could account for evolution and contents of MS lesion.

    • This is not an answer. Most readers of this blog won't attend the research day. Any reason for not sketching a mechanism now? Is it a research secret?

  • If it is on film then you can watch it, so you do not need to be there

    Any reasons…too busy..but I have posted on an example of this aalready already

    • Are you talking about your collaboration with van Noort on heat shock protein HSPB5?

      – Well, you talk about the necessity of neurodegenerative signals. Where do they come from?
      – You say that T-cells damage the tissue. Sorry, the only available data show absence of T-cells in new lesions (this goes for spinal cord also).
      – Is HSPB5 mainly periventricular?
      – Is HSPB5 mainly perivenular?
      – Any data from human CNS that support your hypothesis?

    • Is HSPB5 mainly periventricular? Maybe depend on oligodendrocyte
      – Is HSPB5 mainly perivenular? No in oligodendrocytes
      – Any data from human CNS that support your hypothesis? yes

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