Research: Does Tysabri affect movement in Progression

Cadavid D, Jurgensen S, Lee S. Impact of natalizumab on ambulatory improvement in secondary progressive and disabled relapsing-remitting multiple sclerosis.PLoS One. 2013;8(1):e53297. doi: 10.1371/journal.pone.0053297. Epub 2013 Jan

BACKGROUND:There is an unmet need for disease-modifying therapies to improve ambulatory function in disabled subjects with multiple sclerosis.
OBJECTIVES:Assess the effects of natalizumab on ambulatory function in disabled subjects with relapsing-remitting multiple sclerosis (RRMS) or secondary progressive multiple sclerosis (SPMS).
METHODS:We retrospectively reviewed ambulatory function as measured by timed 25-foot walk (T25FW) in clinical trial subjects with an Expanded Disability Status Scale score ≥3.5, including RRMS subjects from the phase 3 AFFIRM and SENTINEL trials, relapsing SPMS subjects from the phase 2 MS231 study, and nonrelapsing SPMS subjects from the phase 1b DELIVER study. For comparison, SPMS subjects from the intramuscular interferon beta-1a (IM IFNβ-1a) IMPACT study were also analyzed. Improvement in ambulation was measured using T25FW responder status; response was defined as faster walking times over shorter (6-9-month) or longer (24-30-month) treatment periods relative to subjects’ best predose walking times.
RESULTS: There were two to four times more T25FW responders among disabled MS subjects in the natalizumab arms than in the placebo or IM IFNβ-1a arms. Responders walked 25 feet an average of 24%-45% faster than non-responders.
CONCLUSION: Natalizumab improves ambulatory function in disabled RRMS subjects and may have efficacy in disabled SPMS subjects.

Further evidence that if you stop the inflammatory attacks from occurring even in progressive MS, then there can be benefit. The ASCEND trial is in full swing and so we will see if Tysabri influences progression in MS.

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  • Does this mean the researchers looked back at all sorts of other studies where the subjects had been Pw SP or PPMS?

  • Yep retrospective means they did the studies then went back and looked what was the case before the study was completed, a perspective study makes a baseline then does the study and sees what happens. There were SP MSers in the study but I do not think PP MSers were in the study

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