Research: gut bacteria a trigger for MS?

Epub: Banati et al. Antibody response against gastrointestinal antigens in demyelinating diseases of the central nervous system. Eur J Neurol. 2013 Jan 7. doi: 10.1111/ene.12072.

BACKGROUND: Antibodies against gastrointestinal antigens may indicate altered microbiota and immune responses in the gut. Recent experimental data suggest a connection between gastrointestinal immune responses and CNS autoimmunity.

METHODS: Antibodies against gliadin, tissue transglutaminase (tTG), intrinsic factor (IF), parietal cells (PC) and Saccharomyces cerevisiae (ASCA =Yeast) were screened in the sera of 45 patients with AQP4-seropositive neuromyelitis optica (NMO) and NMO spectrum diseases (NMO/NMO-SD), 17 patients with AQP4-seronegative NMO, 85 patients with clinically definite multiple sclerosis (MS), and 48 healthy controls (HC). 

RESULTS: Thirty-seven percentages of patients with AQP4-seropositive NMO/NMO-SD and 28% of patients with MS had at least one particular antibody in contrast to 8% of HC (P < 0.01, respectively). Antibodies were most common (46%) in AQP4-seropositive myelitis (P = 0.01 versus HS, P = 0.05 versus MS). Anti-gliadin and ASCA were more frequent in the AQP4-seropositive NMO-spectrum compared to controls (P = 0.01 and P < 0.05, respectively). 

CONCLUSION: Antibody responses against gastrointestinal antigens are common in MS and AQP4-seropositive NMO/NMO-SD, especially in longitudinally extensive myelitis.

The microbiome which is the gut bacterial flora is hot to trot with immunologists and how the gut flora influences the immune system. Therefore, there are many poor researchers wading through labs full of Pooh. This is further weight towards this argument that MSers and NMOers may have encountered bacteria, fungi (yeast).

About the author


1 comment

  • Hello,
    I've got the diagnosis MS a long time ago. And I experienced a course of a lot of phases with a high frequence of the MS.
    A hollyday trip to africa then changed everything. I got a Malariaprophylaxis for two month with Doxicycline that has started signs like MS symptoms in a cycle time of 10 days. I hadn't stoped the Doxicycline and my situation in the disease turned back to that I had before, except the phases of MS I had before in a high frequence.
    Now, more the 15 Years later, there hasn't been a remarkable worsening of the MS. And after I've got the medical documents about my case, it seems a hidden chronical infection with yersinia enterocolitica has been the reason.
    So I'am shure, there is a link between infection of the gut ans MS. But I think the problem is a dissemination of the bacterial infection to places in the neigbourhood of spaces with fluid with an osmotic gradient from the place of infection to the fluid (i.e. liquor or synovial fluid). Then possibly the gradient of immunological markers show the place of antigenpresentation but not the place of the infection, the antigen supplyer! Autoimmunity against the presentators and anergy against the infection would be the result. Is this a way?

By MouseDoctor



Recent Posts

Recent Comments