The Cost of MS in the USA

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Adelman G, Rane SG, Villa KF. The cost burden of multiple sclerosis in the United States: a systematic review of the literature.J Med Econ. 2013 Feb . [Epub ahead of print]


Objectives: To estimate average annual cost per multiple sclerosis
(MS) patient in the United States using published estimates from the
literature. 
Methods: A search was performed of English-language
literature published between 2007 and June 2012 in PubMed and Embase
using the term ‘multiple sclerosis
and the subject heading ‘healthcare costs’. Included articles were
primary studies with MS cost figures that could be converted to per
patient per year values. Costs were inflated to 2011 dollars using the
medical component of the Consumer Price Index. 
Results: Fifteen
studies met the inclusion criteria. Eight presented only direct cost
calculations; the remaining seven presented estimates of total cost,
broken down into direct and indirect costs. Total all-cause healthcare
costs for MS as reported by studies that included direct and indirect
costs ranged from $8,528 to $54,244 per patient per year. On average,
direct costs comprised 77% (range 64-91%) of total costs. Prescription
medications accounted for the majority of direct costs. On average,
indirect costs comprised 23% (range 9-36%) of total costs. Compared with
direct all-cause medical costs for other chronic conditions reported in
the literature, MS ranked second behind congestive heart failure.
Limitations: Data sources in these studies were dated, ranging from
1999 to 2008, and therefore do not include some of the newer, more
costly therapies. In addition, this review does not include either
assessment of the decrements in quality of life associated with MS or
costs associated with increasing levels of disability or early
retirement. Furthermore, variations in study designs, populations,
methodologies, and cost inputs preclude more precise cost estimates. 
Conclusions: MS is a costly chronic disease. Further research is
needed to understand: costs by MS type, costs associated with increasing
disability and early retirement, and the potential impact of new
treatments expected to launch in coming years.


As major proportion of our readers now come from the USA, this may be of interest to you. As we all can see MS is a costly disease. This data was generated from data published some time ago and the cost will have increased since then 

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