ArchiveMarch 2013

BG12 will cost $54,900 annually

Robert Weisman. Biogen Idec’s new pill to treat MS will cost about $54,900 per patient annually. Boston.com Biogen Idec Inc. said Friday it will price Tecfidera, its newly approved pill to treat multiple sclerosis, at $54,900 a year per patient in the United States. Officials at the Weston-based biotechnology company said the figure represents a “solid value” for MS patients, who will take...

On-line disease monitoring

#MSBlog: Has the era of on-line disease monitoring finally arrived? Not if you are a MSer under the care of the NHS. Epub: Bove et al. Evaluation of an Online Platform for Multiple Sclerosis Research: Patient Description, Validation of Severity Scale, and Exploration of BMI Effects on Disease Course. PLoS One. 2013;8(3):e59707. doi: 10.1371/journal.pone.0059707. OBJECTIVES: To assess...

Research: North South Gradients in Oz assessed by Drug use

Hollingworth S, Walker K, Page A, Eadie M. and the Australian regional prevalence of multiple sclerosis. Mult Scler. 2013. [Epub ahead of print] BACKGROUND: Over some 50 years, field surveys have shown that the prevalence of multiple sclerosis (MS) increases with increasing distance from the equator in both the northern and the southern hemispheres. Such a latitudinal gradient has been found in...

Research Biomarker for Progression

Gnanapavan S, Ho P, Heywood W, Jackson S, Grant D, Rantell K, Keir G, Mills K, Steinman L, Giovannoni G.Progression in multiple sclerosis is associated with low endogenous NCAM. J Neurochem. 2013 Mar 15. doi: 10.1111/jnc.12236. [Epub ahead of print] Multiple sclerosis (MS) is a central nervous system (CNS) disorder characterised by demyelination and neurodegeneration. Although hallmarks of...

CCSVI March 2013

Valdueza JM, Doepp F, Schreiber SJ, van Oosten BW, Schmierer K, Paul F, Wattjes MP. What went wrong? The flawed concept of cerebrospinal venous insufficiency. J Cereb Blood Flow Metab. 2013 Feb 27. doi: 10.1038/jcbfm.2013.31. [Epub ahead of print] In 2006, Zamboni reintroduced the concept that chronic impaired venous outflow of the central nervous system is associated with multiple sclerosis(MS)...

Brain atrophy helps predict the development of disability

#MSBlog: Brain atrophy is more important than you realise. Epub: Popescu et al. Brain atrophy and lesion load predict long term disability in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2013 Mar 23. OBJECTIVE: To determine whether brain atrophy and lesion volumes predict subsequent 10 year clinical evolution in multiple sclerosis (MS). DESIGN: From eight MAGNIMS (MAGNetic resonance Imaging...

Pharma behaving badly in San Diego

Miller JE. Bioethical accreditation or rating needed to restore trust in pharma Nature Medicine 19, 261 (2013) doi:10.1038/nm0313-261. “After years of decline in the public eye, drug companies should implment a bioethics accreditation or rating program to help appropriately restore the industry’s good name and improve its effectiveness in advancing global health and new treatments...

Don’t Crucify the Messenger!

Sometimes we are the bringers of bad news; we don’t necessarily make the bad news. 

So there is no point in venting your ire our way.

Happy Holidays!

Apologies if you think the image is in poor taste; it is Good Friday after all. 

Virally Affected B cells are the Centre of EAE

Epub: Anwar Jagessar et al. The Different Clinical Effects of Anti-BLyS, Anti-APRIL and Anti-CD20 Antibodies Point at a Critical Pathogenic Role of γ-Herpesvirus Infected B Cells in the Marmoset EAE Model. J Neuroimmune Pharmacol. 2013 Mar 19. Background: The robust and rapid clinical effect of depleting anti-CD20 monoclonal antibodies (mAb) in multiple sclerosis (MS) demonstrates a critical...

Research Vitamin D in India

Epub: Pandit et al. Association of vitamin D and multiple sclerosis in India. Mult Scler. 2013 Mar. BACKGROUND: Vitamin D deficiency is widely prevalent in India. The association between vitamin D status and multiple sclerosis (MS) has not been previously studied in Indians. OBJECTIVE: The objective of this paper is to determine whether vitamin D status is associated with MS in India...

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