ArchiveMarch 2013

Research: Measuring Nerve Damage

Epub: Kuhle et al. A comparative study of CSF neurofilament light and heavy chain protein in MS. Mult Scler. 2013 Mar 25.  BACKGROUND: There is a lack of reliable biomarkers of axonal degeneration. Neurofilaments are promising candidates to fulfil this task. We compared two highly sensitive assays to measure two subunits of the neurofilament protein (neurofilament light (NfL)...

AusD study: Vitamin D and sun xpsore in Australia

#MSBlog: Is there a difference between vD from tablets and vD from sunshine? We will have to wait to find out. Epub: Brodie AM, Lucas RM, Harrison SL, van der Mei IA, Armstrong B, Kricker A, Mason RS, McMichael AJ, Nowak M, Whiteman DC, Kimlin MG.The AusD Study: A Population-based Study of the Determinants of Serum 25-Hydroxyvitamin D Concentration Across a Broad Latitude Range. Am J Epidemiol...

Inhibition of Microglia protects Axons

Morsali D, Bechtold D, Lee W, Chauhdry S, Palchaudhuri U, Hassoon P, Snell DM, Malpass K, Piers T, Pocock J, Roach A, Smith KJ. Safinamide and flecainide protect axons and reduce microglial activation in models of multiple sclerosis. Brain. 2013 Mar 20. [Epub ahead of print] Axonal degeneration is a major cause of permanent disability in the inflammatory demyelinating disease multiple...

Childhood MS

#MSBlog: Childhood MS in the spotlight. “This report is timely can confirms the MS communities commitment to children with MS and the need to get DMTs approved for treating childhood MS. Hopefully, parents of children with MS will find this initiative a move in the right direction.” Chitnis et al. International Pediatric MS Study Group Clinical Trials Summit: Meeting report...

Laquinimod inhibits dendritic cell function

Epub: Jolivel et al. Modulation of dendritic cell properties by laquinimod as a mechanism for modulating multiple sclerosis. Brain. 2013 Mar 20.  Laquinimod is an orally administered compound that is under investigation in relapsing-remitting multiple sclerosis. To understand the mechanism by which laquinimod exerts its clinical effects, we have performed human and murine (IT’S MOUSE...

Doctor Ruth Week

Last week saw three papers published by Doctor Ruth, one was a review. Some of the Ram-Magic is clearly rubbing off. Dobson R, Leddy SG, Gangadharan S, Giovannoni G. Assessing fracture risk in people with MS: a service development study comparing three fracture risk scoring systems. BMJ Open. 2013 Mar 11;3(3). doi:pii: e002508. 10.1136/bmjopen-2012-002508. Print 2013. BACKGROUND: Suboptimal...

Cognitive impairment differs between PP and RR MSers

#MSBlog: Is MS shredding your brain? Epub: Ruet et al. Cognitive impairment differs between primary progressive and relapsing-remitting MS. Neurology. 2013 Mar. OBJECTIVES: To characterize the cognitive abilities of MSers with primary progressive multiple sclerosis (PPMS) and relapsing-remitting multiple sclerosis (RRMS) compared with healthy controls (HCs) matched for age, sex, and education...

AAN 2013: more on the safety of oral cladribine

“The following is the safety profile of oral cladribine in the ORACLE or CIS study that was presented at the AAN.” “The most important bit of information buried in this poster is the section on neoplasms.” Neoplasms (malignant, benign, and unspecified) occurred in 1 patient (0.5%) in the cladribine 5.25 mg/kg group (uterine leiomyoma), 3 (1.5%) in the cladribine 3.5...

Endothelin-2 another new factor that promotes remyelination

Epub: Yuen et al. Identification of endothelin 2 as an inflammatory factor that promotes central nervous system remyelination. Brain. 2013 Mar. Background: The development of new regenerative therapies for multiple sclerosis is hindered by the lack of potential targets for enhancing remyelination. The study of naturally regenerative processes such as the innate immune response represents a...

Vocational rehabilitation helps keep you employed. Or does it?

#MSBlog: Vocational rehab and employment status. Chicken or Egg? Talk about stating the obvious. Epub: Chiu et al. State vocational rehabilitation services and employment in multiple sclerosis. Mult Scler. 2013 Mar 21. BACKGROUND: Obtaining and maintaining suitable employment can be a significant challenge for MSers. OBJECTIVE: The objective of this article is to identify what vocational...

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