Research Connecting White and Grey matter lesions

Epub: Mühlau et al .White-matter lesions drive deep gray-matter atrophy in early multiple sclerosis: support from structural MRI. Mult Scler. 2013 Mar 5.

BACKGROUND: In MS, the relationship between lesions within cerebral white matter (WM) and atrophy within deep gray matter (GM) is unclear.

OBJECTIVE: To investigate the spatial relationship between WM lesions and deep GM atrophy.

METHODS: We performed a cross-sectional structural magnetic resonance imaging (MRI) study (3 Tesla) in 249 patients with clinically-isolated syndrome or relapsing-remitting MS (Expanded Disability Status Scale score: median, 1.0; range, 0-4) and in 49 healthy controls. Preprocessing of T1-weighted and fluid-attenuated T2-weighted images resulted in normalized GM images and WM lesion probability maps. We performed two voxel-wise analyses: 1. We localized GM atrophy and confirmed that it is most pronounced within deep GM; 2. We searched for a spatial relationship between WM lesions and deep GM atrophy; to this end we analyzed WM lesion probability maps by voxel-wise multiple regression, including four variables derived from maxima of regional deep GM atrophy (caudate and pulvinar, each left and right).

RESULTS: Atrophy of each deep GM region was explained by ipsilateral WM lesion probability, in the area most densely connected to the respective deep GM region.

CONCLUSION: We demonstrated that WM lesions and deep GM atrophy are spatially related. Our results are best compatible with the hypothesis that WM lesions contribute to deep GM atrophy through axonal pathology.

There is much talk about the influence of grey matter lesions and there are instances where brain slices show grey matter lesions in the apparent absence of space filling white matter lesions. However this study indicates that some of the grey matter lesions are secondary (or primary) to white matter lesions elsewhere in the CNS. This seems obvious to me because nerves bodies in the grey matter connect to axons in the white matter. Damage to one can result in damage to the other. Once the connectome, which is a project to map brain connections, is complete the relationship to white and grey matter lesions will become even clearer.

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