Epub: Preziosi et al. Gut dysfunction in patients with multiple sclerosis and the role of spinal cord involvement in the disease. Eur J Gastroenterol Hepatol. 2013 May 10.
PATIENTS AND METHODS: The Neurogenic Bowel Dysfunction questionnaire and the presence of bladder symptoms were recorded in 71 MSers and bowel symptoms. Disability, a surrogate clinical measure of spinal cord disease, was assessed using the Expanded Disability Status Scale. Bowel and bladder symptoms were quantified by MSer-reported frequency, expressed in time percentage (0, 25, 50, 75 or 100% of the time the symptom was perceived), and MSer-reported severity on a visual analogue scale between 0 and 100.
RESULTS: The prevalence of bladder symptoms was 85%, which is higher than that expected in an unselected population of MSers. Neurogenic Bowel Dysfunction score was significantly correlated with both MSer-reported frequency (r=0.860, P<0.0001) and severity of bowel symptoms (r=0.659, P=<0.0001), as well as with the Expanded Disability Status Scale (r=0.526, P<0.0001).
CONCLUSION: These findings suggest that gut dysfunction in MSers is secondary to spinal cord disease. MSer-reported bowel symptoms quantify bowel dysfunction well.