ArchiveMay 2013

#HealthTalk: Multiple Sclerosis Awareness

Live MS Twitter Chat: Today; Tuesday May 28th, 6pm UK Summer Time or 1 pm EST #HealthTalk #MSBlog “I have volunteered to do a Twitter Chat to honor World MS Day. This is a live Q&A session via Twitter. Although I tweet daily and use Twitter all the time this will be my first live event. You are welcome to sign in to and participate. To participate you will need your own Twitter...

T cells in MS lesions

Fischer MT, Wimmer I, Höftberger R, Gerlach S, Haider L, Zrzavy T, Hametner S, Mahad D, Binder CJ, Krumbholz M, Bauer J, Bradl M, Lassmann H. Disease-specific molecular events in cortical multiple sclerosis lesions. Brain. 2013 May 17. [Epub ahead of print] Cortical lesions constitute an important part of multiple sclerosis pathology. Although inflammation appears to play a role in their...

Survey results: brain atrophy in MS

Brain atrophy our next therapeutic target. #MSBlog #MSResearch “The following are the final brain atrophy survey results. They are very interesting.” “It is clear that there is a knowledge gap, between what you want to know about your disease and what your neurology team are prepared to provide you, or they do not have the data to give you. The only way we are going to get brain...

Survey results: sleep disorders screening

We need to get a grip on sleep disorders in MS; they are common. #MSBlog #MSResearch “Thank you all for completing the sleep disorder survey that has been running on the blog since early April. The following is a precis of the results.” Number of MSers respondents  = 146 Mean age (standard deviation) = 45 yrs (SD 9.9) Youngest respondent  = 23 yrs Oldest respondent = 63 yrs...

Vitamin D supplementation and relapses

High-dose vitamin D supplementation has no impact on relapses. #MSBlog #MSResearch Epub: James et al. The effect of vitamin D-related interventions on multiple sclerosis relapses: a meta-analysis. Mult Scler. 2013 May 22.  Background: Observational studies have shown an association between lower vitamin D levels and higher risk of relapse among MSers. This has raised interest in...

T cell responses to VZV on fingolimod

Fingolimod reduce your T cell immune response to viruses. Is it important? #MSBlog #MSResearch Epub: Ricklin et al. T-cell response against varicella-zoster virus in fingolimod-treated MS patients. Neurology. 2013 May 22. OBJECTIVE: To study the immune response against varicella-zoster virus (VZV) in MSers before and during fingolimod therapy. METHODS: The VZV-specific...

MS lesions formation

“This highly technical paper explains that the migration of white blood cells into the brain and spinal cord of MSers is controlled by a protein that activates the production of enzymes that white cells use to tunnel their way into the brain and spinal cord tissues. By blocking this regulator, with a drug, you could potentially block migration of white cells into the brain and...

Damaging Antibodies they are not all against myelin

Lindner M, Ng JK, Hochmeister S, Meinl E, Linington C. Neurofascin 186 specific autoantibodies induce axonal injury and exacerbate disease severity in experimental autoimmune encephalomyelitis. Exp Neurol. 2013 May 17. doi:pii: S0014-4886(13)00151-9. 10. Axonal injury is considered the major cause of chronic disability in multiple sclerosis (MS) patients, however the mechanisms behind remain...

Interferons for children

Interferon-beta has a similar effect in childhood MS compared to adult-onset disease. #MSBlog #MSResearch Epub: Tenembaum et al. Subcutaneous Interferon Beta-1a in Pediatric Multiple Sclerosis: A Retrospective Study. J Child Neurol. 2013 May 10. Background: To expand current knowledge, this study examined the safety and tolerability of subcutaneous interferon β-1a in MSers with...

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