Epub: Hemmati et al. Neurorestorative effect of FTY720 in a rat model of Alzheimer’s disease: Comparison with Memantine. Behav Brain Res. 2013 Jun. Alzheimer’s disease (AD) as a neurodegenerative brain disorder is the most common cause of dementia. To date, there is no causative treatment for AD and there are few preventive treatments either. The sphingosine-1-phosphate receptor...
Remyelinating fish
Epub: Chung et al. Generation of demyelination models by targeted ablation of oligodendrocytes in the zebrafish CNS. Mol Cells. 2013 Jun 25. Demyelination is the pathological process by which myelin sheaths are lost from around axons, and is usually caused by a direct insult targeted at the oligodendrocytes in the vertebrate central nervous system (CNS). A demyelinated CNS is usually remyelinated...
Icebreaker for the Iceberg Arriving!
Good News for MSers in Europe as Alemtuzumab/Lemtrada gets a first line Licence
It is all about choice, I suspect we will see more of it in the future
Time to break the Iceberg
CCSVI June
Ferra H, Behrens G, Tumer Y, Riemenschneider M. Endovascular diagnosis and management of chronic cerebrospinal venous insufficiency: retrospective analysis of 30-day morbidity and mortality in 95 consecutive patients. AJR Am J Roentgenol. 2013;200(6):1358-64. doi: 10.2214/AJR.12.8938. OBJECTIVE. The purpose of this study is to report the 30-day morbidity and mortality associated with the...
Sodium accumulation in nerves is not good for you
Did people take their drugs Too much sodium is not good for you and I am not talking about salt intake here…but suggests that blocking sodium accumulation in nerves and microglia could be a good idea. So the PROXiMuS trial may not be a bad idea…..The trial is going...
Different Skin Colour but Same MS Genes
Epub: Isobe et al. Genetic risk variants in African Americans with multiple sclerosis. Neurology. 2013 Jun 14. OBJECTIVES: To assess the association of established multiple sclerosis (MS) risk variants in 3,254 African Americans (1,162 cases and 2,092 controls). METHODS: Human leucocyte antigen (HLA)-DRB1, HLA-DQB1, and HLA-A alleles were typed by molecular techniques. Single...
Autoimmunity occurs in MS
Epub: Pedotti et al. Exacerbation of experimental autoimmune encephalomyelitis by passive transfer of IgG antibodies from a multiple sclerosis patient responsive to immunoadsorption. J Neuroimmunol. 2013 Jun 12. The pathogenic role of antibodies in multiple sclerosis (MS) is still controversial. We transferred to mice with experimental autoimmune encephalomyelitis (EAE), animal...
MS Registry MSers in UK
Jones KH, Ford DV, Jones PA, John A, Middleton RM, Lockhart-Jones H, Peng J, Osborne LA, Noble JG How People with Multiple Sclerosis Rate Their Quality of Life: An EQ-5D Survey via the UK MS Register. PLoS One. 2013 Jun 11;8(6):e65640. doi: 10.1371/journal.pone.0065640. Print 2013. The EQ-5D is a widely-used, standardised, quality of life measure producing health profiles, indices and...
Alemtuzumab in mice
Turner MJ, Lamorte MJ, Chretien N, Havari E, Roberts BL, Kaplan JM, Siders WM.Immune status following alemtuzumab treatment in human CD52 transgenic mice. J Neuroimmunol. 2013 Jun 4. doi:pii: S0165-5728(13)00115-X. 10.1016/j.jneuroim.2013.04.018. [Epub ahead of print]Alemtuzumab is a monoclonal antibody against the CD52 antigen present at high levels on the surface of lymphocytes. While...
Time to Lobby?
This is a repost…. There needs to be a political response to help get people access to highly effective DMT. This needs co-ordination……who are the champions? Not this lot? But can they help? All Party Parlimentary Group for Multiple Sclerosis Minster for Health; Jeremy Hunt (Constiuency-South West Surrey) Did you know that there is the All-Party Parliamentary Group...