As I have been saying for sometime, MSers blood contains antibodies against brain tissues and that these are not good for you. In this study they removed antibodies from an MSer and then injected them into an animal with EAE so that the antibodies could get in the brain and this made EAE worse. This clearly demonstrates that there is an autoimmune component that is ongoing in some MSers. What is does not answer is whether this is a primary or secondary problem? What is clear is that it is a problem in MS.
Epub: Pedotti et al. Exacerbation of experimental autoimmune encephalomyelitis by passive transfer of IgG antibodies from a multiple sclerosis patient responsive to immunoadsorption. J Neuroimmunol. 2013 Jun 12.
The pathogenic role of antibodies in multiple sclerosis (MS) is still controversial. We transferred to mice with experimental autoimmune encephalomyelitis (EAE), animal model of MS, IgG antibodies purified from a MS patient presenting a dramatic clinical improvement during relapse after selective IgG removal with immunoadsorption. Passive transfer of patient’s IgG exacerbated motor paralysis and increased mouse central nervous system (CNS) inflammation and demyelination. Binding of patient’s IgG was demonstrated in mouse CNS, with a diffuse staining of white matter oligodendrocytes. These data support a growing body of evidence that antibodies can play an important role in the pathobiology of MS.