Purpose: Although neuropsychological impairments are common in Multiple Sclerosis
(MS), the manifestation of cognitive deficits may vary greatly across
MS patients. Here, we explored the influence of cognitive reserve proxy
indices (education and occupation) and perceived fatigue on cognitive
evaluated. Cognitive performance was measured using the Paced Auditory
Serial Addition Test (PASAT), in which information processing speed can
be manipulated by varying the presentation speed of stimuli.
patients with low education performed worse than healthy controls at
faster PASAT speeds. By contrast, no difference was observed between MS
patients with high education and matched healthy controls, regardless of
PASAT speed. Moreover, we found that neither occupational attainment
nor perceived fatigue has an influence on MS patients’ cognitive
Conclusion: These findings provide evidence that higher
education could be protective against MS-associated cognitive deficits
and that high speed PASAT versions are more suitable for identifying
compensatory capacities compared to low speed PASAT versions.