Interatome Viruses and risk of MS

 Mechelli R, Umeton R, Policano C, Annibali V, Coarelli G, Ricigliano VA, Vittori D, Fornasiero A, Buscarinu MC; International Multiple Sclerosis Genetics Consortium; Wellcome Trust Case Control Consortium,2, Romano S, Salvetti M, Ristori G.A “candidate-interactome” aggregate analysis of genome-wide association data in multiple sclerosis.PLoS One. 2013 May 16;8(5):e63300. doi: 10.1371/journal.pone.0063300. Print 2013.

Though difficult, the study of gene-environment interactions in
multifactorial diseases is crucial for interpreting the relevance of
non-heritable factors and prevents from overlooking genetic associations
with small but measurable effects. We propose a “candidate interactome”
(i.e. a group of genes whose products are known to physically interact
with environmental factors that may be relevant for disease
pathogenesis) analysis of genome-wide association data in multiple sclerosis.
We looked for statistical enrichment of associations among interactomes
that, at the current state of knowledge, may be representative of
gene-environment interactions of potential, uncertain or unlikely
relevance for multiple sclerosis
pathogenesis: Epstein-Barr virus, human immunodeficiency virus,
hepatitis B virus, hepatitis C virus, cytomegalovirus, HHV8-Kaposi
sarcoma, H1N1-influenza, JC virus, human innate immunity interactome for
type I interferon, autoimmune regulator, vitamin D receptor, aryl
hydrocarbon receptor and a panel of proteins targeted by 70 innate
immune-modulating viral open reading frames from 30 viral species.
Interactomes were either obtained from the literature or were manually
curated. The P values of all single nucleotide polymorphism mapping to a
given interactome were obtained from the last genome-wide association
study of the International Multiple Sclerosis
Genetics Consortium & the Wellcome Trust Case Control Consortium,
2. The interaction between genotype and Epstein Barr virus emerges as
relevant for multiple sclerosis aetiology. However, in line with recent data on the coexistence of
common and unique strategies used by viruses to perturb the human
molecular system, also other viruses have a similar potential, though
probably less relevant in epidemiological terms

More evidence for a link between MS and EBV

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