Lin et al. Modulation by Melatonin of the Pathogenesis of Inflammatory Autoimmune Diseases. Int J Mol Sci. 2013;14:11742-11766.
Melatonin is the major secretory product of the pineal gland during the night and has multiple activities including the regulation of circadian and seasonal rhythms, and antioxidant and anti-inflammatory effects. It also possesses the ability to modulate immune responses by regulation of the T helper 1/2 balance and cytokine production. Autoimmune diseases, which result from the activation of immune cells by autoantigens released from normal tissues, affect around 5% of the population. Activation of autoantigen-specific immune cells leads to subsequent damage of target tissues by these activated cells. Melatonin therapy has been investigated in several animal models of autoimmune disease, where it has a beneficial effect in a number of models
Prof Hawkeye form Team G had this idea years ago…Project M……it looks like too much talking and not enough doing has let others come up with the same idea.