Vitamin D low in Msers

Vitamin D levels low in MSers compared to familial controls. #MSBlog #MSResearch

Mazdeh et al. Comparison of Vitamin D3 Serum Levels in New Diagnosed Patients with Multiple Sclerosis versus Their Healthy Relatives. Acta Med Iran. 2013; 51:289-92.

Background: Multiple risk factors are introduced for Multiple Sclerosis (MS). Recent studies have suggested a possible correlation between vitamin D deficiency and an increase risk of MS.

Objective: This study was therefore undertaken to compare vitamin D levels in new cases of MS and their relatives as healthy controls.

Methods: Seventy five new diagnosed MS patients and 100 matched healthy controls among their relatives were enrolled in this study. Two groups were matched for gender, age, season in which serum level of vitamin D was checked and region and diet. Serum levels of 25-hydroxy vitamin D was measured, recorded and analyzed.

Results: Seventy five patients (57 female and 18 male) and 100 healthy subjects (75 female and 25 male) were enrolled in this study. The mean serum levels of 25-hydroxy vitamin D in case and control groups were 11.31 and 17.9 ng/ml, respectively (P=0.003). Compared to the healthy subject, serum levels of vitamin D were significantly lower in patients with MS. This difference was only significant in women. Observed difference of vitamin D levels of both groups were significant in summer.

Conclusion: This study continues to support the role of vitamin D deficiency in MS.

What does this mean did people with MS have lower vitamin D levels and was only different in summer and the MSer when outside less. Is this chicken or egg?

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  • One problem with just considering the level of 25(OH)D in the blood is that there are 2 possible reasons one person has a higher level than the other. The first is obvious that they consume/create more. The second is more complex, it is how good you are at using the last bit. If you have a jar of Marmite and you are very poor at scrapping out the last bit then, when some one observes, you will always have more Marmite than someone who is better at cleaning out the jar. If the Viking gene is about conserving vitamin d to control calcium in the blood then at low levels it will conserve vitamin d and you may appear to have a higher level than someone who cannot.

  • Interesting that the significantly lower levels were found in women also much larger number of female compared to male patients. Cultural effect?

  • The skin cancer scare has an obvious effect. All makeup comes with an SPF factor. A woman might look more attractive in makeup but there is less skin exposed to receive sunlight and thus less vitamin D is produced by the body.

    • This study is from Iran, I suspect the widespread enforcement of veiling since the revolution in the 80's may be a contributory factor here.

  • People on this blog have often said that the actual disease (MS) uses up a lot of vitamin D to keep itself going, which thus results in MSers having lower bone density.

    How and why does the MS use vitamin D, and are feeding a monster by upping our vitamin D levels?

    • Bone density is affected by loss of calcium as it is used to control the levels of calcium in the blood. This process is controlled by the 1,25(OH)D and the parathyroid hormones. Oddly when people are depleted in 25(OH)D the levels of 1,25(OH)D in the blood go up. There is as far as I know no evidence that vitamin d feeds MS. I guess this idea comes from the Marshall Protocol people

    • There is no evidence published anywhere that provides any evidence that vitamin d feeds any immune system disease, except the computer modelling carried out by those who push the Marshall Protocol. They believe that most autoimmune diseases are caused by bacteria hiding in the body. They also believe that vitamin d helps the bacteria hide from the body, and so try and treat these diseases by reducing vitamin d intake and taking antibiotics for years. I came across this belief 7 years ago and since then all the evidence produced has said the opposite, that although vitamin d suppresses the active immune system it does it by increasing the innate system so there is less inflammation and therefore less need for the active system. Vitamin d in the blood has two forms, 1,25(OH)D, which is the active hormone and 25(OH)D which is a delivery/storage form, so it can be stored in the blood. By taking vitamin d it is converted to 25(OH)D and then delivered as required by cells, where it is converted to 1,25(OH)D in a tightly controlled manner. The levels of the active hormone in the blood are very much lower than the storage form.

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