This is an actual comment from a referee……Brutal.
“The authors of the grant applications have confused two entirely different neurological disorders in animals and humans. EAE is an artificial animal model of inflammatory demyelination that bears no resemblance to MS, particularly non-relapsing progressive MS. EAE and MS are clinically and histologically different, and several hundreds of experimental treatment shown to be effective in EAE never worked in MS because chronic EAE is not chronic MS. The proposed solution of the researchers based on chronic EAE model is highly aspirational and is not likely to translate into an effective treatment of human disease”.
There are a lot of clinicians who think this way and their voice is being listened to more and more.
However, decorum prevents me from providing ProfG’s description of this person….However, I suspect it is not in the same league of abuse that will come from the author of the grant
Hope your grant doesn’t go to this guy/gal…Hope too he/she doesn’t get any disease because with no animal work in the development process in phase 0, there will be few for the future. So 6 months wasted.
I wonder why someone who feels so “anti-animal experiments” would agree to spend their time actually reviewing a translational drug-development grant in a call from the Medical Research Council for drug development……to make comments that have no purpose other than ensure the work never gets done.