ArchiveJuly 2013

Pregnancy- Epidurals and MS

Lu E, Zhao Y, Dahlgren L, Preston R, van der Kop M, Synnes A, Sadovnick AD, Traboulsee A, Tremlett H. Obstetrical epidural and spinal anesthesia in multiple sclerosis. J Neurol. 2013  [Epub ahead of print] To examine obstetrical epidural and spinal anesthesia use in women with multiple sclerosis (MS) and the relationship with MS clinical factors. This was a retrospective (Already done and...

Degrading antibodies

Challa DK, Bussmeyer U, Khan T, Montoyo HP, Bansal P, Ober RJ, Ward ES. Autoantibody depletion ameliorates disease in murine experimental autoimmune encephalomyelitis.MAbs. 2013 19;5. [Epub ahead of print] Much data support a role for central nervous system antigen-specific antibodies in the pathogenesis of multiple sclerosis (MS). The effects of inducing a decrease in (auto)antibody levels on MS...

Prognostic value of MRI

Zhang WY, Hou YL. Prognostic value of magnetic resonance imaging in patients with clinically isolated syndrome conversion to multiple sclerosis: A meta-analysis.Neurol India. 2013;61(3):231-8Background: Numerous studies have investigated the associations of brain or spinal cord MRI with the risk of developing Multiple Sclerosis (MS) in people with Clinically Isolated Syndrome (CIS), however, the...

Risk of MS and children

Hedström A, Hillert J, Olsson T, Alfredsson L. Reverse causality behind the association between reproductive history and MS. Mult Scler. 2013 Jul 25. [Epub ahead of print] BACKGROUND:Possible associations between childbearing patterns and multiple sclerosis (MS) risk have been studied for a long time, with conflicting results. We aimed to investigate the influence of reproductive history on MS...

Tysabri and Endogenous Retro virus.

Arru G, Leoni S, Pugliatti M, Mei A, Serra C, Delogu LG, Manetti R, Dolei A, Sotgiu S, Mameli G.Natalizumab inhibits the expression of human endogenous retroviruses of the W family in multiple sclerosis patients: a longitudinal cohort study. Mult Scler. 2013 Jul 22. [Epub ahead of print] BACKGROUND: Several viruses were reported as co-factors triggering the pathogenesis of multiple sclerosis...

Macrophages nick target for daclizumab from T cells

Zhang Y, McClellan M, Efros L, Shi D, Bielekova B, Tang M, Vexler V, Sheridan J. Daclizumab reduces CD25 levels on T cells through monocyte-mediated trogocytosis.  Mult Scler. 2013 Jul  [Epub ahead of print] Daclizumab is a humanized monoclonal antibody that prevents interleukin-2 (IL-2) binding to CD25, blocking IL-2 signaling by cells that require high-affinity IL-2 receptors to...

Next time they have a moan

Next time your partner has a moan…suggest they get some weights and go for a walk. As part of our Public Engagement we have been spending our weekends talking to Children of MSers. There are lots of fun tasks and running round a track with weights on your legs is a way of explaining why mum or dad can’t walk as freely as they would like.  Sometimes Dads will have a go too. Are...

Placebo Effect

Mechanisms and therapeutic implications of the placebo effect in neurological and psychiatric conditions.Murray D, Stoessl AJ. Pharmacol Ther. 2013. doi:pii: S0163-7258(13)00155-1. 10.1016/j.pharmthera.2013.07.009. [Epub ahead of print] The power of a placebo to effect clinically meaningful neurobiological change comparable to pharmacological therapies has been demonstrated, although the...

Factors in the spinal fluid that can stimulate nerve growth and myelin formation

Cristofanilli M, Cymring B, Lu A, Rosenthal H, Sadiq SA. Cerebrospinal fluid derived from progressive multiple sclerosis patients promotes neuronal and oligodendroglial differentiation of human neural precursor cells in vitro. Neuroscience. 2013 Jul  doi:pii: S0306-4522(13)00604-0.10.1016/j.neuroscience. 2013.07.022. [Epub ahead of print] In the adult central nervous system (CNS), tissue...

CCSVI July..Its CCSVI super saturday…

#MSResearch #MSblog CCVSI is not causal in MS Dolic K, Siddiqui AH, Karmon Y, Marr K, Zivadinov R. The role of noninvasive and invasive diagnostic imaging techniques for detection of extra-cranial venous system anomalies and developmental variants. BMC Med. 2013 Jun 27;11(1):155. [Epub ahead of print] The extra-cranial venous system is complex and not well studied in comparison to...

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